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p53 Products

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406253
UNC0646
featured
UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent se…
406254
UNC0631
featured
UNC-0631 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent se…
406433
Tenovin-6 HCl
featured
Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic a…
406723
Tenovin-1
featured
Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation.
406236
SP-600125
featured
SP-600125 is a specific JNK inhibitor. SP600125 kills p53-deficient cells more efficiently than thei…
406130
Sirtinol
featured
Sirtinol is a SIRT inhibitor. Sirtinol significantly increased the acetylation of p53, which has bee…
406347
SAR-020106
featured
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L…
406182
RO-3306
featured
RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with …
406413
OK-1035
OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate…
406308
Nutlin-3a
featured
Nutlin-3a, also known as SML 0580, is an inhibitor of MDM2 (human homolog of murine double minute 2…
406385
NU6027
featured
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and c…
406382
MPI-0479605
featured
MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479…
406161
JNJ-7706621
featured
JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependen…
406518
Inauhzin
featured
Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity,…
406302
FTI-2153
FTI-2153 is a potent farnesyltransferase inhibitor. FTI-2153 inhibits bipolar spindle formation duri…
406299
FTI-276
FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimeti…
406341
CHIR-124
featured
CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other…
406339
BPR1K653
BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifica…
406291
AC17
AC17, a novel 4-arylidene curcumin analog, is a potent 19S deubiquitinase inhibitors with great pote…
406583
9-hydroxyellipticine HCl
featured
9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agen…
206014
XK469
XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiprolifer…
202650
Voreloxin
featured
Voreloxin, also known as SNS-595 or Vosaroxin, is a s mall molecule and a naphthyridine analogue wit…
205781
Triphendiol
Triphendiol, also known as NV-196, is a synthetic isoflavene . Triphendiol (NV-196) is another inves…
206217
PF-04929113 free base
featured
PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 9…
203190
Sepantronium bromide
featured
Sepantronium bromide, also known as YM-155, is a small-molecule proapoptotic agent with potential an…
206223
Sabarubicin
Sabarubicin, also known as BMS195615 and MEN10755, is a disaccharide analogue of the anthracycline …
202421
RO5045337
new
featured
RO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity.
205917
Idasanutlin (RG7388)
featured
Idasanutlin, also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist wi…
202701
Resveratrol
featured
Resveratrol (also known as SRT-501) is a phytoalexin derived from grapes and other food products wit…
206119
Recilisib sodium
featured
Recilisib, also known as ON 01210.Na, is a radioprotectant, which modifys cell cycle distribution pa…
201916
Niraparib HCl
featured
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potenti…
205979
Mitoguazone
Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively i…
206069
MI-773
featured
MI-773 is a new small molecule inhibitor of the MDM2-p53 interaction, binds to MDM2 with high affini…
201561
INO-1001
INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose)…
206159
Siremadlin
featured
Siremadlin, also known as HDM201, is an orally bioavailable human double minute 2 homolog (HDM2) inh…
205922
Geldanamycin
featured
Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and …
206063
Milademetan tosylate
Milademetan, also known as DS-3032b or DS-3032, is a potent and selective MDM2 inhibitor with potent…
200848
CX-5461
featured
CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol…
205957
CGM097
featured
CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential a…
206212
Carbendazim
featured
Carbendazim is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. It…
205951
Bizelesin
Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the …
204676
BIIB028
BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic a…
204560
Roniciclib
Roniciclib, also known as BAY 1000394; is an orally bioavailable cyclin dependent kinase (CDK) inhib…
200284
ARQ-501
featured
ARQ-501, also known as beta-lapachone, is a naphthoquinone compound derived from bark of Tabebuia s…
205947
ARQ-171
ARQ-171 is a second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 17…
205945
Eprenetapopt (APR-246)
featured
APR-246, also known as PRIMA-1MET and Eprenetapopt, is a quinuclidinone derivative that targets the …
200123
AFP-464 free base
AFP-464 is a synthetic lysyl prodrug of the amino-substituted flavone derivate aminoflavone with ant…
200090
ADPM06
ADPM06 is an emerging non-porphyrin PDT agent which has been specifically designed for therapeutic a…
100940
Vorinostat
featured
Vorinostat, also known as suberanilohydroxamic acid, MK-0683 and SAHA, is a potent and selective in…
406514
SB225002
featured
SB225002 is a novel and potent microtubule inhibitor and CXCR2 antagonist with potential anticancer …