WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 204676
CAS#: 911398-13-5 (free acid)
Description: BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.
MedKoo Cat#: 204676
Name: BIIB028
CAS#: 911398-13-5 (free acid)
Chemical Formula: C19H21ClN5O5P
Exact Mass: 465.0969
Molecular Weight: 465.8308
Elemental Analysis: C, 48.99; H, 4.54; Cl, 7.61; N, 15.03; O, 17.17; P, 6.65
Related CAS #: 911398-12-4 (sodium) 911398-13-5 (free acid)
Synonym: BIIB028; BIIB 028; BIIB-028.
IUPAC/Chemical Name: 4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yn-1-yl dihydrogen phosphate
InChi Key: BMZGPNGECPQAGB-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21ClN5O5P/c1-11-8-22-14(12(2)16(11)29-3)10-25-9-13(6-4-5-7-30-31(26,27)28)15-17(20)23-19(21)24-18(15)25/h8-9H,5,7,10H2,1-3H3,(H2,21,23,24)(H2,26,27,28)
SMILES Code: CC1=CN=C(CN2C=C(C#CCCOP(O)(O)=O)C3=C(Cl)N=C(N)N=C32)C(C)=C1OC
