Newest Products

AZD8186

CAT#: 406260
CAS#: 1627494-13-6

AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic...

GSK-J4 free base

CAT#: 555282
CAS#: 1373423-53-0 (free base)

GSK-J4 is a cell permeable, potent and selective histone demethylase. GSK-J4 is a prodrug of GSK J1, which is the...

SBE-13 HCl

CAT#: 406445
CAS#: 1052532-15-6

SBE-13 is a selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μ M for PLK1, PLK3 and PLK2...

GSK-461364

CAT#: 205667
CAS#: 929095-18-1

GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with...

GSK-2033

CAT#: 523111
CAS#: 1221277-90-2

GSK-2033 is a potent cell-active LXR antagonist (pIC50 = 7.5). It enhances T-cell proliferation and blocks T...

GSK-189254 free base

CAT#: 500804
CAS#: 720690-73-3 (free base)

GSK-189254 is a potent and selective H3-receptor inverse agonist. It has subnanomolar affinity for the H3 receptor...

Ulodesine

CAT#: 206081
CAS#: 548486-59-5

Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor in development as a once-daily...

Otenabant HCl

CAT#: 502501
CAS#: 686347-12-6 (HCl)

Otenabant, also known as CP-945,598, is a drug which acts as a potent and highly selective CB1 antagonist. It was...

GO-6976

CAT#: 406206
CAS#: 136194-77-9

GO 6976, also known as PD-406976, is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. GÃ¶ 6976...

GNE-477

CAT#: 471024
CAS#: 1032754-81-6

GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kα) and mTOR (apparent Ki = 21 nM).

OTS514 HCl

CAT#: 558256
CAS#: 2319647-76-0 (HCl)

OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect...

SAR-405

CAT#: 406844
CAS#: 1523406-39-4

SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition...

Givinostat HCl

CAT#: 206814
CAS#: 199657-29-9 (HCl)

Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with...

W-9 HCl

CAT#: 556133
CAS#: 69762-85-2 (HCl)

W-9 is a Calmodulin antagonist

CAIX Inhibitor S4

CAT#: 462420
CAS#: 1330061-67-0

CAIX Inhibitor S4 is an inhibitor of carbonic anhydrase IX. It is selective for CAIX over CAI and CAII but does...

RS 100329 HCl

CAT#: 532581
CAS#: 215654-26-4 (HCl)

RS 100329 is a subtype-selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors). RS 100329...

LYS-006

CAT#: 555854
CAS#: 1799681-85-8

LYS-006 is a Leukotriene A4 hydrolase (LTA4H) inhibitor for the treatment of Hidradenitis Suppurativa.

NB-360 free base

CAT#: 555240
CAS#: 1262857-73-7 (free base)

NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust...

TCS-2210

CAT#: 556132
CAS#: 1201916-31-5

TCS 2210 is a small molecule inducer of neuronal differentiation.

TCS PIM-1 1

CAT#: 574899
CAS#: 491871-58-0

TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor.

BMS303141

CAT#: 510276
CAS#: 943962-47-8

BMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with...

trans-ISRIB

CAT#: 530345
CAS#: 1597403-47-8 (trans-isomer)

trans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2α phosphorylation-mediated...

XEN445

CAT#: 510290
CAS#: 1515856-92-4

XEN445 is potent and selective endothelial lipase inhibitor, that showed good ADME and PK properties, and...

VU0364439

CAT#: 526782
CAS#: 1246086-78-1

VU0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).

ZCL-278

CAT#: 531341
CAS#: 587841-73-4

ZCL-278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase.