VU534
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MedKoo CAT#: 124791

CAS#: 923509-20-0

Description: VU534 is a NAPE-PLD activator with an EC50 of 0.30 μM. Several lines of evidence suggest that reduced NAPE-PLD activity could contribute to cardiometabolic diseases. VU534 was shown to increase efferocytosis by bone-marrow derived macrophages isolated from wild-type mice, while efferocytosis was significantly reduced in Napepld-/- BMDM or after Nape-pld inhibition.

Chemical Structure

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VU534
CAS# 923509-20-0
Instruction

Theoretical Analysis

MedKoo Cat#: 124791
Name: VU534
CAS#: 923509-20-0
Chemical Formula: C21H22FN3O3S2
Exact Mass: 447.11
Molecular Weight: 447.540
Elemental Analysis: C, 56.36; H, 4.96; F, 4.25; N, 9.39; O, 10.72; S, 14.33

Price and Availability

Size Price Availability Quantity
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2950 2 Weeks
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Synonym: VU534; VU-534; VU 534

IUPAC/Chemical Name: N-(5,7-dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide

InChi Key: RLHUIVPGYWWIQZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22FN3O3S2/c1-13-11-14(2)19-18(12-13)23-21(29-19)24-20(26)15-7-9-25(10-8-15)30(27,28)17-5-3-16(22)4-6-17/h3-6,11-12,15H,7-10H2,1-2H3,(H,23,24,26)

SMILES Code: CC1=CC(C)=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: May 7, 2024- Product VU534 Patent licensing News MedKoo is excited to announce the licensing of patents of the novel compound VU534 from Vanderbilt University. VU534, a breakthrough compound, is now featured on our website at https://medkoo.com/products/55763. VU534 is a NAPE-PLD activator with an EC50 of 0.30 μM. Several lines of evidence suggest that reduced NAPE-PLD activity could contribute to cardiometabolic diseases. VU534 was shown to increase efferocytosis by bone-marrow derived macrophages isolated from wild-type mice, while efferocytosis was significantly reduced in Napepld-/- BMDM or after Nape-pld inhibition. . This groundbreaking product is safeguarded by patents including World Patent WO 2023/201014 A1

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 447.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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