10-DEBC hydrochloride
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MedKoo CAT#: 574659

CAS#: 925681-41-0

Description: 10-DEBC hydrochloride is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt. Inhibition of Akt phosphorylation by this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.


Chemical Structure

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10-DEBC hydrochloride
CAS# 925681-41-0

Theoretical Analysis

MedKoo Cat#: 574659
Name: 10-DEBC hydrochloride
CAS#: 925681-41-0
Chemical Formula: C20H26Cl2N2O
Exact Mass: 380.1422
Molecular Weight: 381.34
Elemental Analysis: C, 62.99; H, 6.87; Cl, 18.59; N, 7.35; O, 4.20

Price and Availability

Size Price Availability Quantity
1.0mg USD 215.0 2 Weeks
5.0mg USD 395.0 2 Weeks
10.0mg USD 575.0 2 Weeks
50.0mg USD 1095.0 2 Weeks
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Synonym: 10-DEBC HCl; 10-DEBC hydrochloride; Akt Inhibitor X

IUPAC/Chemical Name: 2-chloro-N,N-diethyl-10H-phenoxazine-10-butanamine, monohydrochloride

InChi Key: SVKSJUIYYCQZEC-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H

SMILES Code: ClC1=CC2=C(C=C1)OC3=CC=CC=C3N2CCCCN(CC)CC.Cl

Appearance: A crystalline solid

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 381.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Thimmaiah, K.N., Easton, J.B., Germain, G.S., et al. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. The Journal of Biological Chemisty 280(36), 31924-31935 (2005).