WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463157
CAS#: 52050-17-6
Description: 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides. They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells when used at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a concentration-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen and brain, thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingosine (d18:1) isolated from bovine buttermilk.
MedKoo Cat#: 463157
Name: 1-β-D-Glucosylsphingosine
CAS#: 52050-17-6
Chemical Formula: C24H47NO7
Exact Mass: 461.3353
Molecular Weight: 461.64
Elemental Analysis: C, 62.44; H, 10.26; N, 3.03; O, 24.26
Synonym: 1-β-D-Glucosylsphingosine; Glucosyl-C18-sphingosine; Glucosylsphingosine (d18:1); 1-β-D-Glucosylsphingosine (d18:1) (buttermilk);
IUPAC/Chemical Name: (2R,3R,4S,5S,6R)-2-(((2S,3R,E)-2-amino-3-hydroxyoctadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChi Key: HHJTWTPUPVQKNA-JIAPQYILSA-N
InChi Code: InChI=1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1
SMILES Code: O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[C@H](N)[C@@H](/C=C/CCCCCCCCCCCCC)O)CO)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 461.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
