10-DEBC free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562826

CAS#: 201788-90-1 (free base)

Description: 10-DEBC, also known as Akt Inhibitor X and CCG-206734, is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt. Inhibition of Akt phosphorylation by this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.

Chemical Structure

10-DEBC free base
CAS# 201788-90-1 (free base)

Theoretical Analysis

MedKoo Cat#: 562826
Name: 10-DEBC free base
CAS#: 201788-90-1 (free base)
Chemical Formula: C20H25ClN2O
Exact Mass: 344.1655
Molecular Weight: 344.883
Elemental Analysis: C, 69.65; H, 7.31; Cl, 10.28; N, 8.12; O, 4.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 201788-90-1 (free base)   925681-41-0 (HCl)    

Synonym: Akt Inhibitor X; Akt Inhibitor-X; aktX; 10-DEBC hydrochloride; CCG-206734; CCG 206734; CCG206734; NCP;

IUPAC/Chemical Name: 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine


InChi Code: InChI=1S/C20H25ClN2O/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 344.883 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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9: Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, Uhlén P, Estrada M. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol. 2009 Aug;202(2):299-307. doi: 10.1677/JOE-09-0044. Epub 2009 May 27. Erratum in: J Endocrinol. 2009 Sep;202(3):485. PubMed PMID: 19474060.

10: Lim CS, Walikonis RS. Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway. Cell Signal. 2008 May;20(5):825-35. doi: 10.1016/j.cellsig.2007.12.013. Epub 2007 Dec 27. PubMed PMID: 18262389; PubMed Central PMCID: PMC2302788.