GS-441524 solution
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555700

CAS#: 1191237-69-0

Description: GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. Note: This product is supplied as 10mg /mL solution (see additional information for recipe of the solution.


Price and Availability

Size
Price

10mg
USD 190
100mg
USD 1050
1g
USD 3450
Size
Price

25mg
USD 350
200mg
USD 1450
2g
USD 6450
Size
Price

50mg
USD 650
500mg
USD 2450

GS-441524 solution, 10mg/mL, is in stock. This product can be shipped in the same day after order is received. Note: This product is only for research use. We do not sell product for personal use


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555700
Name: GS-441524 solution
CAS#: 1191237-69-0
Chemical Formula: C12H13N5O4
Exact Mass: 291.0968
Molecular Weight: 291.267
Elemental Analysis: C, 49.48; H, 4.50; N, 24.04; O, 21.97


Synonym: GS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite;

IUPAC/Chemical Name: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

InChi Key: BRDWIEOJOWJCLU-LTGWCKQJSA-N

InChi Code: InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1

SMILES Code: N#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@H](CO)[C@@H](O)[C@H]1O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


Additional Information

Note:
GS-441524 solution was prepared in 10mg /mL followed procedure described in below paper:
Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281.
This paper is available on line: url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435921/

Solution composition (all by volume):
5% ethanol, 30% propylene glycol, 45% PEG 400, 20 % water (pH 1.5 with HCl).


References

1: Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281. doi: 10.1177/1098612X19825701. Epub 2019 Feb 13. PubMed PMID: 30755068; PubMed Central PMCID: PMC6435921.

2: Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233. doi: 10.1016/j.vetmic.2018.04.026. Epub 2018 Apr 22. PubMed PMID: 29778200.