GS-441524
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555299

CAS#: 1191237-69-0 (free base)

Description: GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM.. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 120 Same day
200mg USD 215 Same day
500mg USD 450 Same day
1g USD 750 Same day
2g USD 1250 Same day
5g USD 1850 Same day
10g USD 2950 Same day
100g USD 9950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-19. Prices are subject to change without notice.

GS-441524, purity > 98%, is in stock. Note: Our product GS-441524 is a Pure chemical in Powder form for laboratory research use only. It is NOT a FDA approved medicine, and can NOT be used for any treatment or clinical trials! Your order will NOT be fulfilled unless the order is coming from biotech, pharmaceutical-related business, an academic or a government institute!


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555299
Name: GS-441524
CAS#: 1191237-69-0 (free base)
Chemical Formula: C12H13N5O4
Exact Mass: 291.0968
Molecular Weight: 291.1
Elemental Analysis: C, 49.48; H, 4.50; N, 24.04; O, 21.97


Related CAS #: 1191237-69-0 (free base)   2378280-82-9 (HCl)   2378280-83-0 (sulfate)    

Synonym: GS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite;

IUPAC/Chemical Name: (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile

InChi Key: BRDWIEOJOWJCLU-LTGWCKQJSA-N

InChi Code: InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1

SMILES Code: N#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@H](CO)[C@@H](O)[C@H]1O


Technical Data

Appearance:
Solid powder

Purity:
>97% (or refer to the Certificate of Analysis)

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats.
Note: Chemical structure was from MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.
https://mbio.asm.org/content/9/2/e00221-18/figures-only

For preparation of GS-441524 stock solution, customer may use below protocol, which was published
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435921/

Drug preparation
GS-441524 was diluted to a concentration of 10 or 15 mg/ml in 5% ethanol, 30% propylene glycol, 45% PEG 400, 20% water (pH 1.5 with HCl). The mixture was placed in sterile 50 ml glass injection bottles, agitated until in suspension, and then placed in a sonicated water bath for 5–20 mins until clear. The diluted drug was refrigerated and used within 3–4 weeks.


References

1: Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281. doi: 10.1177/1098612X19825701. Epub 2019 Feb 13. PubMed PMID: 30755068; PubMed Central PMCID: PMC6435921.

2: Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233. doi: 10.1016/j.vetmic.2018.04.026. Epub 2018 Apr 22. PubMed PMID: 29778200.