Chloramphenicol sodium succinate | CAS# 982-57-0 (sodium succinate) | bacterial infections

Chloramphenicol sodium succinate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412839

CAS#: 982-57-0 (sodium succinate)

Description: Chloramphenicol sodium succinate injection is an antibiotic used to treat serious bacterial infections. The most serious side effect of chloramphenicol is bone marrow suppression. Common side effects of chloramphenicol sodium succinate include: diarrhea.

Chemical Structure

Chloramphenicol sodium succinate

CAS# 982-57-0 (sodium succinate)

Instruction

Theoretical Analysis

MedKoo Cat#: 412839
Name: Chloramphenicol sodium succinate
CAS#: 982-57-0 (sodium succinate)
Chemical Formula: C15H15Cl2N2NaO8
Exact Mass: 444.01
Molecular Weight: 445.180
Elemental Analysis: C, 40.47; H, 3.40; Cl, 15.93; N, 6.29; Na, 5.16; O, 28.75

Price and Availability

Size	Price	Availability
1g	USD 250	2 Weeks
2g	USD 350	2 Weeks
5g	USD 550	2 Weeks
10g	USD 850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Chloramphenicol sodium succinate; CCRIS6204; CCRIS-6204; CCRIS 6204

IUPAC/Chemical Name: sodium 4-((2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoate

InChi Key: RPLOPBHEZLFENN-HTMVYDOJSA-M

InChi Code: InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1

SMILES Code: O[C@H](c1ccc([N+]([O-])=O)cc1)[C@H](NC(C(Cl)Cl)=O)COC(CCC([O-])=O)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kauffman RE, Thirumoorthi MC, Buckley JA, Aravind MK, Dajani AS. Relative bioavailability of intravenous chloramphenicol succinate and oral chloramphenicol palmitate in infants and children. J Pediatr. 1981 Dec;99(6):963-7. doi: 10.1016/s0022-3476(81)80034-0. PMID: 7310593.

2: Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9(3):222-38. doi: 10.2165/00003088-198409030-00004. PMID: 6375931.

3: Burke JT, Wargin WA, Sherertz RJ, Sanders KL, Blum MR, Sarubbi FA. Pharmacokinetics of intravenous chloramphenicol sodium succinate in adult patients with normal renal and hepatic function. J Pharmacokinet Biopharm. 1982 Dec;10(6):601-14. doi: 10.1007/BF01062543. PMID: 7182457.

4: Nahata MC, Powell DA. Comparative bioavailability and pharmacokinetics of chloramphenicol after intravenous chloramphenicol succinate in premature infants and older patients. Dev Pharmacol Ther. 1983;6(1):23-32. doi: 10.1159/000457274. PMID: 6839912.

5: Black LA, McLachlan AJ, Griffith JE, Higgins DP, Gillett A, Krockenberger MB, Govendir M. Pharmacokinetics of chloramphenicol following administration of intravenous and subcutaneous chloramphenicol sodium succinate, and subcutaneous chloramphenicol, to koalas (Phascolarctos cinereus). J Vet Pharmacol Ther. 2013 Oct;36(5):478-85. doi: 10.1111/jvp.12024. Epub 2012 Nov 17. PMID: 23157306.

6: Shann F, Linnemann V, Mackenzie A, Barker J, Gratten M, Crinis N. Absorption of chloramphenicol sodium succinate after intramuscular administration in children. N Engl J Med. 1985 Aug 15;313(7):410-4. doi: 10.1056/NEJM198508153130703. PMID: 4022068.

7: Kauffman RE, Miceli JN, Strebel L, Buckley JA, Done AK, Dajani AS. Pharmacokinetics of chloramphenicol and chloramphenicol succinate in infants and children. J Pediatr. 1981 Feb;98(2):315-20. doi: 10.1016/s0022-3476(81)80670-1. PMID: 7463235.

8: Brown MP, Kelly RH, Gronwall RR, Stover SM. Chloramphenicol sodium succinate in the horse: serum, synovial, peritoneal, and urine concentrations after single-dose intravenous administration. Am J Vet Res. 1984 Mar;45(3):578-80. PMID: 6711989.

9: Nahata MC, Powell DA. Bioavailability and clearance of chloramphenicol after intravenous chloramphenicol succinate. Clin Pharmacol Ther. 1981 Sep;30(3):368-72. doi: 10.1038/clpt.1981.174. PMID: 7273601.

10: Nahata MC. Simultaneous measurement of chloramphenicol sodium succinate and chloramphenicol in presence of furosemide in plasma and urine. J Clin Pharm Ther. 1993 Aug;18(4):301. doi: 10.1111/j.1365-2710.1993.tb00592.x. PMID: 8227239.

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