Chloramphenicol stearate

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MedKoo CAT#: 598730

CAS#: 16255-48-4 (stearate)

Description: Chloramphenicol stearate is an antibiotic useful for the treatment of a number of bacterial infections. This includes as an eye ointment to treat conjunctivitis.

Chemical Structure

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Chloramphenicol stearate
CAS# 16255-48-4 (stearate)
Instruction

Theoretical Analysis

MedKoo Cat#: 598730
Name: Chloramphenicol stearate
CAS#: 16255-48-4 (stearate)
Chemical Formula: C29H46Cl2N2O6
Exact Mass: 588.27
Molecular Weight: 589.590
Elemental Analysis: C, 59.08; H, 7.86; Cl, 12.03; N, 4.75; O, 16.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 31342-36-6 (pantothenate complex)   982-57-0 (sodium succinate)   3544-94-3 (succinate)   16255-48-4 (stearate)   530-43-8 (palmitate)   716-61-0 (base)   56-75-7 (free)  

Synonym: Chloramphenicol stearate; Eusynthomycin; Madomicetina; Chloramphenicol monostearate;

IUPAC/Chemical Name: (2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propyl stearate

InChi Key: IDWDXHQLOMJDRU-XNMGPUDCSA-N

InChi Code: InChI=1S/C29H46Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-26(34)39-22-25(32-29(36)28(30)31)27(35)23-18-20-24(21-19-23)33(37)38/h18-21,25,27-28,35H,2-17,22H2,1H3,(H,32,36)/t25-,27-/m1/s1

SMILES Code: CCCCCCCCCCCCCCCCCC(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 589.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: BAGGIO GC. [Modification of utilization of chloramphenicol stearate in relation to age]. Acta Paediatr Lat. 1953 May-Jun;6(3):317-22. Undetermined Language. PubMed PMID: 13147825.

2: BARON A. [Utilization of chloramphenicol stearate in pediatrics]. Acta Pediatr Esp. 1954 Jan;11(133):100-1. Undetermined Language. PubMed PMID: 13147903.

3: Cameroni R, Coppi G, Forni F, Gamberini G, Ferioli V. [Pseudomorphism of chloramphenicol stearate and palmitate in relationship availability]. Farmaco Prat. 1983 Apr;38(4):173-82. Italian. PubMed PMID: 6861978.

4: BARON A. [The use of chloramphenicol stearate in pediatrics]. Acta Pediatr Esp. 1953 Aug;11(128):737-8. Undetermined Language. PubMed PMID: 13113965.

5: CANTARUTTI F. [One year of clinical experience with chloramphenicol stearate]. Acta Paediatr Lat. 1953 May-Jun;6(3):259-70. Undetermined Language. PubMed PMID: 13147820.

6: ALMIRANTE L, DE CARNERI I, COPPI G. [Relation between the therapeutic activity and the crystalline and amorphous state of chloramphenicol stearate]. Farmaco Prat. 1960 Aug;15:471-82. Italian. PubMed PMID: 14448291.

7: Bernabei MT, Coppi G, Cameroni R. [Effect of surfactants on the in vitro enzymatic hydrolysis of chloramphenicol stearate]. Farmaco Prat. 1981 Jun;36(6):294-303. Italian. PubMed PMID: 7274410.

8: Cameroni R, Bernabei MT, Forni F, Coppi G. Polymorphism of chloramphenicol stearate. II - Kinetics of solid-state transition of crystal forms. Farmaco Prat. 1978 Oct;33(10):447-54. PubMed PMID: 750230.

9: Cameroni R, Gamberini G, Forni F, Coppi G, Ferioli V, Bernabei MT. [Polymorphism of chloramphenicol stearate]. Farmaco Prat. 1978;33(4):141-61. Italian. PubMed PMID: 729772.

10: Bernabei MT, Coppi G, Forni F, Cameroni R, Galli E. [Determination of the crystallinity of biologically active polymorph forms of chloramphenicol stearate: correlation with in vitro enzymatic hydrolysis]. Farmaco Prat. 1979 Aug;34(8):338-46. Italian. PubMed PMID: 540661.

11: Forni F, Iannuccelli V, Cameroni R. Surface area and crystallinity of Form A of chloramphenicol palmitic and stearic esters: which one is the limiting factor in the enzymatic hydrolysis? J Pharm Pharmacol. 1987 Dec;39(12):1041-3. PubMed PMID: 2894436.