AZD-4769

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206215

CAS#: 127481-29-2 (free)

Description: AZD-4769, also known as L 674573, is a leukotriene biosynthesis inhibitor.

Chemical Structure

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AZD-4769
CAS# 127481-29-2 (free)
Instruction

Theoretical Analysis

MedKoo Cat#: 206215
Name: AZD-4769
CAS#: 127481-29-2 (free)
Chemical Formula: C28H27NO3S
Exact Mass: 457.17
Molecular Weight: 457.588
Elemental Analysis: C, 73.50; H, 5.95; N, 3.06; O, 10.49; S, 7.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 127481-29-2 (free)   AZD-4769 sodium    

Synonym: AZD4769; AZD-4769; AZD 4769; L 674573; L-674573; L674573; L-674,573; L 674,573; L674,573;

IUPAC/Chemical Name: 2-((4-phenyl-1-(4-(quinolin-2-ylmethoxy)phenyl)butyl)thio)acetic acid

InChi Key: JOIXGLLMSDPZDN-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H27NO3S/c30-28(31)20-33-27(12-6-9-21-7-2-1-3-8-21)23-14-17-25(18-15-23)32-19-24-16-13-22-10-4-5-11-26(22)29-24/h1-5,7-8,10-11,13-18,27H,6,9,12,19-20H2,(H,30,31)

SMILES Code: O=C(O)CSC(C1=CC=C(OCC2=NC3=CC=CC=C3C=C2)C=C1)CCCC4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:        

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 457.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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 1: Mancini JA, Prasit P, Coppolino MG, Charleson P, Leger S, Evans JF, Gillard JW, Vickers PJ. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. PMID: 1538707.


2: Kargman S, Prasit P, Evans JF. Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. J Biol Chem. 1991 Dec 15;266(35):23745-52. PMID: 1748650.