Tylvalosin free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573594

CAS#: 63409-12-1 (free base)

Description: Tylvalosin is a macrolide antibiotic. It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 µg/ml, respectively). Tylvalosin (5 and 10 µg/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 (PGE2), and nitric oxide in RAW 264.7 cells. It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water. Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.

Chemical Structure

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Tylvalosin free base
CAS# 63409-12-1 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 573594
Name: Tylvalosin free base
CAS#: 63409-12-1 (free base)
Chemical Formula: C53H87NO19
Exact Mass: 1,041.59
Molecular Weight: 1,042.270
Elemental Analysis: C, 61.08; H, 8.41; N, 1.34; O, 29.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 63428-13-7 (tartrate)   63409-12-1 (free base)   63428-14-8 (HCl)   1453840-14-6 (phosphate)  

Synonym: Aivlosin, Tylvalosin ; Acetylisovaleryltylosin;

IUPAC/Chemical Name: (4R,5S,6S,7R,9R,11E,13E,15R,16R)-15-(((6-Deoxy-2,3-di-O-methyl-beta-D-allopyranosyl)oxy)methyl)-6-((3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-4-O-(3-methylbutanoyl)-alpha-L-ribo-hexopyranosyl)-3-(dimethylamino)-beta-D-glucopyranosyl)oxy)-16-ethyl-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-4-yl acetate

InChi Key: KCJJINQANFZSAM-HZDSEHBESA-N

InChi Code: InChI=1S/C53H87NO19/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3/b18-17+,28-22+/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-/m1/s1

SMILES Code: CC(O[C@H]1[C@@H]([C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)[C@@H]([C@@H](C)O2)O[C@@H]3O[C@H]([C@@H]([C@@](O)(C)C3)OC(CC(C)C)=O)C)[C@@H](CC=O)C[C@@H](C)C(/C=C/C(C)=C/[C@H](CO[C@@H]4O[C@@H]([C@@H](O)[C@@H](OC)[C@H]4OC)C)[C@@H](CC)OC(C1)=O)=O)C)=O

Appearance: Solid powder

Purity: 80 % (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,042.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Moges R, De Lamache DD, Sajedy S, Renaux BS, Hollenberg MD, Muench G, Abbott EM, Buret AG. Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB(4) Production, While Inducing the Release of Pro-Resolving Lipoxin A(4) and Resolvin D1. Front Vet Sci. 2018 Apr 11;5:57. doi: 10.3389/fvets.2018.00057. eCollection 2018. PubMed PMID: 29696149; PubMed Central PMCID: PMC5905233.

2: Pallarés FJ, Lasa C, Roozen M, Ramis G. Use of tylvalosin in the control of porcine enzootic pneumonia. Vet Rec Open. 2015 Jun 30;2(1):e000079. doi: 10.1136/vetreco-2014-000079. eCollection 2015. PubMed PMID: 26392896; PubMed Central PMCID: PMC4567154.

3: Zhao Z, Tang X, Zhao X, Zhang M, Zhang W, Hou S, Yuan W, Zhang H, Shi L, Jia H, Liang L, Lai Z, Gao J, Zhang K, Fu L, Chen W. Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Biochem Pharmacol. 2014 Jul 1;90(1):73-87. doi: 10.1016/j.bcp.2014.04.015. Epub 2014 Apr 30. PubMed PMID: 24792436.