Tylvalosin tartrate
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MedKoo CAT#: 464768

CAS#: 63428-13-7 (tartrate)

Description: Tylvalosin is a macrolide antibiotic. It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 µg/ml, respectively). Tylvalosin (5 and 10 µg/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 (PGE2), and nitric oxide in RAW 264.7 cells. It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water. Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.


Chemical Structure

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Tylvalosin tartrate
CAS# 63428-13-7 (tartrate)

Theoretical Analysis

MedKoo Cat#: 464768
Name: Tylvalosin tartrate
CAS#: 63428-13-7 (tartrate)
Chemical Formula: C57H93NO25
Exact Mass: 0.00
Molecular Weight: 1,192.353
Elemental Analysis: C, 57.42; H, 7.86; N, 1.17; O, 33.55

Price and Availability

Size Price Availability Quantity
100mg USD 350 Ready to ship
500mg USD 550 Ready to ship
1g USD 950 2 Weeks
5g USD 2950 2 Weeks
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Related CAS #: 63428-13-7 (tartrate)   63409-12-1 (free base)   63428-14-8 (HCl)   1453840-14-6 (phosphate)    

Synonym: Tylvalosin tartrate; Acetylisovaleryltylosin tartrate;

IUPAC/Chemical Name: (2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6R)-6-(((4R,5S,6S,7R,9R,11E,13E,15R,16R)-4-acetoxy-16-ethyl-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (2R,3R)-2,3-dihydroxysuccinate

InChi Key: OLLSDNUHBJHKJS-XKORHJEPSA-N

InChi Code: InChI=1S/C53H87NO19.C4H6O6/c1-16-38-36(26-65-52-49(64-15)48(63-14)44(60)31(7)67-52)22-28(4)17-18-37(57)29(5)23-35(19-20-55)46(30(6)39(69-34(10)56)24-41(59)70-38)73-51-45(61)43(54(12)13)47(32(8)68-51)72-42-25-53(11,62)50(33(9)66-42)71-40(58)21-27(2)3;5-1(3(7)8)2(6)4(9)10/h17-18,20,22,27,29-33,35-36,38-39,42-52,60-62H,16,19,21,23-26H2,1-15H3;1-2,5-6H,(H,7,8)(H,9,10)/b18-17+,28-22+;/t29-,30+,31-,32-,33+,35+,36-,38-,39-,42+,43-,44-,45-,46-,47-,48-,49-,50+,51+,52-,53-;1-,2-/m11/s1

SMILES Code: OC([C@@H]([C@H](C(O)=O)O)O)=O.CN([C@@H]([C@@H]1O[C@H]2C[C@@]([C@@H](OC(CC(C)C)=O)[C@H](C)O2)(C)O)[C@@H](O)[C@H](O[C@H]3[C@@H](CC=O)C[C@@H](C)C(/C=C/C(C)=C/[C@H](CO[C@H]4[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O4)[C@@H](CC)OC(C[C@@H](OC(C)=O)[C@@H]3C)=O)=O)O[C@@H]1C)C

Appearance: Solid powder

Purity: >80% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Safety Data Sheet (SDS):
Biological target: Tylvalosin tartrate (Acetylisovaleryltylosin tartrate) is a macrolide antibiotic that can against Gram-positive bacteria.
In vitro activity: TBD
In vivo activity: Clinical signs of the disease were more evident in the untreated group than in the treated group. The average daily weight gain, average daily feed consumption and feed conversion efficiency were better in the treated group. The combined length of intestine with lesions was 2847 cm in the untreated group and 183 cm in the treated group. The tylvalosin treatment significantly reduced the level of L intracellularis infection; almost half of the treated pigs were IHC-negative compared with 3.3 per cent of the untreated pigs. Reference: Guedes RM, França SA, Machado GS, Blumer MA, da Costa Cruz EC Jr. Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. Vet Rec. 2009 Sep 19;165(12):342-5. doi: 10.1136/vr.165.12.342. PMID: 19767637.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 25.16
DMSO 30.0 25.16
Ethanol 30.0 25.16

Preparing Stock Solutions

The following data is based on the product molecular weight 1,192.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Guedes RM, França SA, Machado GS, Blumer MA, da Costa Cruz EC Jr. Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. Vet Rec. 2009 Sep 19;165(12):342-5. doi: 10.1136/vr.165.12.342. PMID: 19767637.
In vitro protocol: TBD
In vivo protocol: Guedes RM, França SA, Machado GS, Blumer MA, da Costa Cruz EC Jr. Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. Vet Rec. 2009 Sep 19;165(12):342-5. doi: 10.1136/vr.165.12.342. PMID: 19767637.

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1: Guedes RM, França SA, Machado GS, Blumer MA, da Costa Cruz EC Jr. Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. Vet Rec. 2009 Sep 19;165(12):342-5. doi: 10.1136/vr.165.12.342. PMID: 19767637.