Chlorothiazide
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MedKoo CAT#: 592507

CAS#: 58-94-6 (free)

Description: Chlorothiazide is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.

Chemical Structure

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Chlorothiazide
CAS# 58-94-6 (free)
Instruction

Theoretical Analysis

MedKoo Cat#: 592507
Name: Chlorothiazide
CAS#: 58-94-6 (free)
Chemical Formula: C7H6ClN3O4S2
Exact Mass: 294.95
Molecular Weight: 295.712
Elemental Analysis: C, 28.43; H, 2.05; Cl, 11.99; N, 14.21; O, 21.64; S, 21.68

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Related CAS #: 58-94-6 (free)   7085-44-1 (sodium)  

Synonym: Chlorothiazide

IUPAC/Chemical Name: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide

InChi Key: JBMKAUGHUNFTOL-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

SMILES Code: O=S(C1=C(Cl)C=C(C2=C1)N=CNS2(=O)=O)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 295.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501520/ PubMed PMID: 30000580.

2: Spirk D, Noll S, Burnier M, Rimoldi S, Noll G, Sudano I. Effect of Home Blood Pressure Monitoring on Patient's Awareness and Goal Attainment Under Antihypertensive Therapy: The Factors Influencing Results in Anti-HypertenSive Treatment (FIRST) Study. Kidney Blood Press Res. 2018;43(3):979-986. doi: 10.1159/000490687. Epub 2018 Jun 15. PubMed PMID: 29940594.

3: Park K, Trout LC, Xu C, Wang M, Tamburro RF, Halstead ES. No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children. Pediatr Crit Care Med. 2018 Jun 20. doi: 10.1097/PCC.0000000000001608. [Epub ahead of print] PubMed PMID: 29927879.

4: Lee AS, Bowen DK, Vatsky S, Zderic SA, Tasian GE. Percutaneous nephrolithotomy in an 8-week-old infant. Can J Urol. 2018 Jun;25(3):9363-9365. PubMed PMID: 29900827.

5: Schollée JE, Bourgin M, von Gunten U, McArdell CS, Hollender J. Non-target screening to trace ozonation transformation products in a wastewater treatment train including different post-treatments. Water Res. 2018 Oct 1;142:267-278. doi: 10.1016/j.watres.2018.05.045. Epub 2018 May 25. PubMed PMID: 29890475.

6: Eadon MT, Kanuri SH, Chapman AB. Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment. Expert Rev Precis Med Drug Dev. 2018;3(1):33-47. doi: 10.1080/23808993.2018.1420419. Epub 2018 Jan 3. PubMed PMID: 29888336; PubMed Central PMCID: PMC5990020.

7: Katsi V, Athanasiadi E, Tsioufis C, Tousoulis D. Azilsartan and Chlorthalidone-new Powerful Fixed dose Antihypertensive Combination. Curr Hypertens Rev. 2018;14(1):15-20. doi: 10.2174/1573402114666180420170816. PubMed PMID: 29683095.

8: Liu Y, Dai S, Liu L, Liao H, Xiao C. Spironolactone is superior to hydrochlorothiazide for blood pressure control and arterial stiffness improvement: A prospective study. Medicine (Baltimore). 2018 Apr;97(16):e0500. doi: 10.1097/MD.0000000000010500. PubMed PMID: 29668634; PubMed Central PMCID: PMC5916657.

9: Fayed AS, Rezk MR, Marzouk HM, Abbas SS. A Capillary Zone Electrophoresis Method with Multiresponse Chemometric Optimization for the Simultaneous Determination of Zofenopril Calcium and Hydrochlorothiazide in Presence of Hydrochlorothiazide Major Impurities. J Chromatogr Sci. 2018 Mar 15. doi: 10.1093/chromsci/bmy014. [Epub ahead of print] PubMed PMID: 29554245.

10: Sbeih F, Christov F, Gluth MB. Newly Diagnosed Meniere's Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine. Ann Otol Rhinol Laryngol. 2018 May;127(5):331-337. doi: 10.1177/0003489418763224. Epub 2018 Mar 16. PubMed PMID: 29546771.

11: Arroll B, Wallace H. Should we switch from bendrofluazide to chlorthalidone as the initial treatment for hypertension? A review of the available medication. J Prim Health Care. 2017 Jun;9(2):105-113. doi: 10.1071/HC16038. PubMed PMID: 29530222.

12: Orth LE, O'Mara KL. Impact of Early Versus Late Diuretic Exposure on Metabolic Bone Disease and Growth in Premature Neonates. J Pediatr Pharmacol Ther. 2018 Jan-Feb;23(1):26-33. doi: 10.5863/1551-6776-23.1.26. PubMed PMID: 29491749; PubMed Central PMCID: PMC5823489.

13: Sung KC, Oh YS, Cha DH, Hong SJ, Won KH, Yoo KD, Rha SW, Ahn YK, Ahn JC, Jang JY, Hong TJ, Cho SK, Park SH, Hyon MS, Nam CW, Chae IH, Yoo BS, Song JM, Jeong JO, Yoon YW, Kim BS, Yang TH, Cho DK, Kim SH, Choi YJ, Ahn JH, Jeon DW, Kim HS. Efficacy and Tolerability of Telmisartan/Amlodipine + Hydrochlorothiazide Versus Telmisartan/Amlodipine Combination Therapy for Essential Hypertension Uncontrolled With Telmisartan/Amlodipine: The Phase III, Multicenter, Randomized, Double-blind TAHYTI Study. Clin Ther. 2018 Jan;40(1):50-63.e3. doi: 10.1016/j.clinthera.2017.11.006. Epub 2017 Dec 14. PubMed PMID: 29248384.

14: de Diego M, Godoy R, Mennickent S, Vergara C, Miranda D, Navarro P. Stability-Indicating Liquid Chromatographic Methods with Photodiode Array Detection and Light Scattering Detection for Simultaneous Determination of Candesartan and Hydrochlorothiazide. J Chromatogr Sci. 2018 Feb 1;56(2):99-107. doi: 10.1093/chromsci/bmx068. PubMed PMID: 29236956.

15: Nakao S, Hatahira H, Sasaoka S, Hasegawa S, Motooka Y, Ueda N, Abe J, Fukuda A, Naganuma M, Kanoh H, Seishima M, Ishiguro M, Kinosada Y, Nakamura M. Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database. Biol Pharm Bull. 2017;40(12):2158-2165. doi: 10.1248/bpb.b17-00561. PubMed PMID: 29199239.

16: de Almeida CLB, Cechinel-Filho V, Boeing T, Mariano LNB, Silva LMD, Andrade SF, de Souza P. Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats: Role of antioxidant system and renal protection. Chem Biol Interact. 2018 Jan 5;279:227-233. doi: 10.1016/j.cbi.2017.11.021. Epub 2017 Dec 1. PubMed PMID: 29198636.

17: Bourgin M, Beck B, Boehler M, Borowska E, Fleiner J, Salhi E, Teichler R, von Gunten U, Siegrist H, McArdell CS. Evaluation of a full-scale wastewater treatment plant upgraded with ozonation and biological post-treatments: Abatement of micropollutants, formation of transformation products and oxidation by-products. Water Res. 2018 Feb 1;129:486-498. doi: 10.1016/j.watres.2017.10.036. Epub 2017 Oct 20. PubMed PMID: 29190578.

18: MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P, Mackenzie IS, Padmanabhan S, McCann GP, Salsbury J, McInnes G, Brown MJ; British Hypertension Society Programme of Prevention And Treatment of Hypertension With Algorithm‐based Therapy (PATHWAY). Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial. J Am Heart Assoc. 2017 Nov 18;6(11). pii: e006986. doi: 10.1161/JAHA.117.006986. PubMed PMID: 29151036; PubMed Central PMCID: PMC5721778.

19: Armaković SJ, Armaković S, Četojević-Simin DD, Šibul F, Abramović BF. Photocatalytic degradation of 4-amino-6-chlorobenzene-1,3-disulfonamide stable hydrolysis product of hydrochlorothiazide: Detection of intermediates and their toxicity. Environ Pollut. 2018 Feb;233:916-924. doi: 10.1016/j.envpol.2017.08.090. Epub 2017 Nov 7. PubMed PMID: 29122364.

20: Ashcheulova T, Gerasimchuk N, Rezunenko Y, Demydenko G, Kochubiei O. PATHOGENETIC ADVANCES OF FOSINOPRIL SODIUM WITH HYDROCHLOROTHIAZIDE IN OBESE HYPERTENSIVE PATIENTS. Georgian Med News. 2017 Oct;(271):55-61. PubMed PMID: 29099702.