M2698 free base

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MedKoo CAT#: 407496

CAS#: 1379545-95-5 (free base)

Description: M2698, also known as MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K).

Price and Availability

Size Price Shipping out time Quantity
200mg USD 2950 2 Weeks
500mg USD 3650 2 Weeks
1g USD 4850 2 Weeks
2g USD 8950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

M2698 is in stock

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 407496
Name: M2698 free base
CAS#: 1379545-95-5 (free base)
Chemical Formula: C21H19ClF3N5O
Exact Mass: 449.123
Molecular Weight: 449.8622
Elemental Analysis: C, 56.07; H, 4.26; Cl, 7.88; F, 12.67; N, 15.57; O, 3.56

Related CAS #: 1379545-95-5 (free base)   M2698 HCl    

Synonym: M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A.

IUPAC/Chemical Name: (S)-4-((2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethyl)amino)quinazoline-8-carboxamide


InChi Code: InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1

SMILES Code: O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: