M2698 free base
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MedKoo CAT#: 407496

CAS#: 1379545-95-5 (free base)

Description: M2698, also known as MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K).


Chemical Structure

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M2698 free base
CAS# 1379545-95-5 (free base)

Theoretical Analysis

MedKoo Cat#: 407496
Name: M2698 free base
CAS#: 1379545-95-5 (free base)
Chemical Formula: C21H19ClF3N5O
Exact Mass: 449.123
Molecular Weight: 449.8622
Elemental Analysis: C, 56.07; H, 4.26; Cl, 7.88; F, 12.67; N, 15.57; O, 3.56

Price and Availability

Size Price Availability Quantity
200.0mg USD 2950.0 2 Weeks
500.0mg USD 3650.0 2 Weeks
1.0g USD 4850.0 2 Weeks
2.0g USD 8950.0 2 Weeks
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Related CAS #: 1379545-95-5 (free base)   M2698 HCl    

Synonym: M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A.

IUPAC/Chemical Name: (S)-4-((2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethyl)amino)quinazoline-8-carboxamide

InChi Key: HXAUJHZZPCBFPN-QGZVFWFLSA-N

InChi Code: InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1

SMILES Code: O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 449.8622 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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