M2698 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206164

CAS#: 1379545-95-5 (free base)

Description: MSC2363318A, also known as M2698, is an orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor MSC2363318A binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase.


Price and Availability

Size
Price

1g
Ask price
Size
Price

2g
Ask price
Size
Price

5g
Ask price

M2698 HCl is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 206164
Name: M2698 HCl
CAS#: 1379545-95-5 (free base)
Chemical Formula: C21H20Cl2F3N5O
Exact Mass:
Molecular Weight: 486.3202
Elemental Analysis: C, 51.87; H, 4.15; Cl, 14.58; F, 11.72; N, 14.40; O, 3.29


Related CAS #: 1379545-95-5 (free base)   CAS# for HCl is unknown  

Synonym: M2698 HCl; M2698 Hhydrochloride; MSC2363318A; MSC 2363318A; MSC-2363318A; M2698; M-2698; M 2698.

IUPAC/Chemical Name: (S)-4-((2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethyl)amino)quinazoline-8-carboxamide hydrochloride

InChi Key: AVLBEMHEKRLPQR-UNTBIKODSA-N

InChi Code: InChI=1S/C21H19ClF3N5O.ClH/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20;/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29);1H/t17-;/m1./s1

SMILES Code: O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


Additional Information

  
 
 
 


References