FY26

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406767

CAS#: 1255143-82-8

Description: FY26 is a potent Os(II) anticancer drug candidate, exerts its activity by generating reactive oxygen species and disrupting the redox balance in cancer cells Coadministration of FY26 and nontoxic doses of L-BSO allows the potentiation of its anticancer activity, and most remarkably, it improves the selectivity for cancer cells versus normal fibroblasts. FY26 is 49 times more potent than the clinically used treatment Cisplatin. FY26 is able to shut down a cancer cell by exploiting weaknesses inherent in their energy generation.

Chemical Structure

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FY26
CAS# 1255143-82-8
Instruction

Theoretical Analysis

MedKoo Cat#: 406767
Name: FY26
CAS#: 1255143-82-8
Chemical Formula: C23H28F6IN4OsP
Exact Mass: 0.00
Molecular Weight: 822.604
Elemental Analysis: C, 33.58; H, 3.43; F, 13.86; I, 15.43; N, 6.81; Os, 23.13; P, 3.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1255143-82-8   255143-81-7 (cation)    

Synonym: FY26; FY-26; FY 26.

IUPAC/Chemical Name: Osmium(1+)​, [N,​N-​dimethyl-​4-​[2-​(2-​pyridinyl-​κN)​diazenyl-​κN1]​benzenamine]​iodo[(1,​2,​3,​4,​5,​6-​η)​-​1-​methyl-​4-​(1-​methylethyl)​benzene]​-​, hexafluorophosphate(​1-​) (1:1)

InChi Key:

InChi Code:

SMILES Code: CC1=CC=C(C(C)C)C=C1>>CN(C)C2=CC=C([N]3=NC4=CC=CC=[N]4[Os+]3I)C=C2.F[P-](F)(F)(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 822.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Fu Y.; Habtemariam A.; Pizarro A. M.; van Rijt S. H.; Healey D. J.; Cooper P.; Shnyder S. D.; Clarkson G. J.; Sadler P. J. Organometallic Osmium Arene Complexes with Potent Cancer Cell Cytotoxicity. J. Med. Chem. 2010, 53, 8192–8196.10.1021/jm100560f

2. Romero-Canelón I, Mos M, Sadler PJ. Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation. J Med Chem. 2015 Oct 8;58(19):7874-80. doi: 10.1021/acs.jmedchem.5b00655. Epub 2015 Sep 23. PubMed PMID: 26397305; PubMed Central PMCID: PMC4601049.