GYKI-16638 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526611

CAS#: 307556-59-8 (HCl)

Description: GYKI-16638 is a novel antiarrhythmic agent. GYKI-16638 has an in vivo antiarrhythmic effect, comparable to that of D-sotalol. GYKI 16638 in human ventricular muscle shows combined Class IB and Class III antiarrhythmic properties, resembling the electrophysiological manifestation seen after chronic amiodarone treatment.

Chemical Structure

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GYKI-16638 HCl
CAS# 307556-59-8 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 526611
Name: GYKI-16638 HCl
CAS#: 307556-59-8 (HCl)
Chemical Formula: C21H31ClN2O5S
Exact Mass: 0.00
Molecular Weight: 458.998
Elemental Analysis: C, 54.95; H, 6.81; Cl, 7.72; N, 6.10; O, 17.43; S, 6.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 307556-59-8 (HCl)   778564-77-5 (free base),  

Synonym: GYKI-16638; GYKI 16638; GYKI16638; GYKI-16,638; GYKI 16,638; GYKI16,638.

IUPAC/Chemical Name: N-(4-(2-((1-(2,6-dimethoxyphenoxy)propan-2-yl)(methyl)amino)ethyl)phenyl)methanesulfonamide hydrochloride

InChi Key: DEVXAIVAHHEHKR-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H30N2O5S.ClH/c1-16(15-28-21-19(26-3)7-6-8-20(21)27-4)23(2)14-13-17-9-11-18(12-10-17)22-29(5,24)25;/h6-12,16,22H,13-15H2,1-5H3;1H

SMILES Code: CS(=O)(NC1=CC=C(CCN(C(C)COC2=C(OC)C=CC=C2OC)C)C=C1)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 459.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mátyus P, Varga I, Rettegi T, Simay A, Kállay N, Károlyházy L, Kocsis A, Varró
A, Pénzes I, Papp JG. Novel antiarrhythmic compounds with combined class IB and
class III mode of action. Curr Med Chem. 2004 Jan;11(1):61-9. Review. PubMed
PMID: 14754426.


2: Opincariu M, Varró A, Iost N, Virág L, Hála O, Szolnoki J, Szécsi J, Bogáts G,
Szenohradszky P, Mátyus P, Papp JG. The cellular electrophysiologic effect of a
new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human
ventricular muscle: comparison with sotalol and mexiletine. Curr Med Chem. 2002
Jan;9(1):41-6. PubMed PMID: 11860346.


3: Baczkó I, El-Reyani NE, Farkas A, Virág L, Iost N, Leprán I, Mátyus P, Varró
A, Papp JG. Antiarrhythmic and electrophysiological effects of GYKI-16638, a
novel N-(phenoxyalkyl)-N-phenylalkylamine, in rabbits. Eur J Pharmacol. 2000 Sep
15;404(1-2):181-90. PubMed PMID: 10980278.