AXN65820 | CAS# 100165-82-0 | Synthetic porphyrin derivative

AXN65820
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 161100

CAS#: C56H52CoN4

Description: AXN65820 , also known as Co(II) meso-Tetra (2,4,6-trimethylphenyl) porphine, is a catalyst for the intramolecular ring-closing of azides, as well as being studied as a potential catalyst for living radical polymerization.

Chemical Structure

AXN65820

CAS# C56H52CoN4

Instruction

Theoretical Analysis

MedKoo Cat#: 161100
Name: AXN65820
CAS#: C56H52CoN4
Chemical Formula: C56H52CoN4
Exact Mass: 839.35
Molecular Weight: 840.000
Elemental Analysis: C, 80.07; H, 6.24; Co, 7.02; N, 6.67

Price and Availability

Size	Price	Availability
25mg	USD 720	2 Weeks
50mg	USD 1100	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Co(II) meso-Tetra (2,4,6-trimethylphenyl) porphine

IUPAC/Chemical Name: n/a

InChi Key: AFWJXYNTLVOWIW-XYIYAAJRSA-N

InChi Code: InChI=1S/C56H52N4.Co/c1-29-21-33(5)49(34(6)22-29)53-41-13-15-43(57-41)54(50-35(7)23-30(2)24-36(50)8)45-17-19-47(59-45)56(52-39(11)27-32(4)28-40(52)12)48-20-18-46(60-48)55(44-16-14-42(53)58-44)51-37(9)25-31(3)26-38(51)10;/h13-28H,1-12H3;/q-2;+2/b53-41+,53-42+,54-43+,54-45+,55-44+,55-46+,56-47+,56-48+;

SMILES Code: CC(C=C1C)=CC(C)=C1/C(C2=CC=C3N2[Co]N4/C(C=C/C4=C(C5=N/C(C=C5)=C3/C6=C(C)C=C(C)C=C6C)\C7=C(C)C=C(C)C=C7C)=C8/C9=C(C)C=C(C)C=C9C)=C%10N=C8C=C/%10

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 840.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1.) Kuijpers, et al. Cobalt-Porphyrin-Catalysed Intramolecular Ring-Closing C−H Amination of Aliphatic Azides: A Nitrene-Radical Approach to Saturated Heterocycles. Chemistry, a European Journal. Volume 23, Issue 33, June 12, 2017, Pages 7945-7952. https://doi.org/10.1002/chem.201700358

2.) Harden, et al. Cobalt-catalyzed intermolecular C–H amination with bromamine-T as nitrene source. Chem. Commun., 2007, 4644-4646.https://doi.org/10.1039/B710677G

3.) Li, et al. Exchange of Organic Radicals with Organo-Cobalt Complexes Formed in the Living Radical Polymerization of Vinyl Acetate. J. Am. Chem. Soc. 2008, 130, 40, 13373–13381. https://doi.org/10.1021/ja804010h

4.) Zhao, et al. Visible Light Induced Living/Controlled Radical Polymerization of Acrylates Catalyzed by Cobalt Porphyrins. Macromolecules 2014, 47, 18, 6238–6245. https://doi.org/10.1021/ma5014385

5.) Peng, et al. Formation and Interconversion of Organo-Cobalt Complexes in Reactions of Cobalt(II) Porphyrins with Cyanoalkyl Radicals and Vinyl Olefins. Inorg. Chem. 2009, 48, 11, 5039–5046. https://doi.org/10.1021/ic900384n

6.) Chan, et al. Electronic Effects of Ligands on the Cobalt(II)–Porphyrin-Catalyzed Direct C–H Arylation of Benzene. EurJIC. Volume 2012, Issue3, January 2012, Pages 485-489. https://doi.org/10.1002/ejic.201100780

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