NT-0249
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MedKoo CAT#: 127536

CAS#: 2763617-39-4

Description: NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity.

Chemical Structure

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NT-0249
CAS# 2763617-39-4
Instruction

Theoretical Analysis

MedKoo Cat#: 127536
Name: NT-0249
CAS#: 2763617-39-4
Chemical Formula: C22H28N5NaO4S
Exact Mass: 481.18
Molecular Weight: 481.547
Elemental Analysis: C, 54.87; H, 5.86; N, 14.54; Na, 4.77; O, 13.29; S, 6.66

Price and Availability

Size Price Availability Quantity
50mg USD 1250 2 Weeks
100mg USD 2050 2 Weeks
1g USD 4950 2 Weeks
Bulk inquiry

Synonym: NT-0249; NT 0249; NT0249

IUPAC/Chemical Name: sodium (S)-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(N-(1-methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)amide

InChi Key: VIQOIGVHQODXOY-FERBBOLQSA-M

InChi Code: InChI=1S/C22H29N5O4S.Na/c1-26-13-17(12-23-26)27(14-18-7-4-10-31-18)32(29,30)25-22(28)24-21-19-8-2-5-15(19)11-16-6-3-9-20(16)21;/h11-13,18H,2-10,14H2,1H3,(H2,24,25,28);/q;+1/p-1/t18-;/m0./s1

SMILES Code: O=C([N-]S(N(C1=CN(C)N=C1)C[C@@H]2CCCO2)(=O)=O)NC3=C4C(CCC4)=CC5=C3CCC5.[Na+]

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 481.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Thornton P, Reader V, Digby Z, Smolak P, Lindsay N, Harrison D, Clarke N, Watt AP. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826. doi: 10.1124/jpet.123.002013. PMID: 38336379.