Brovanexine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126622

CAS#: 54340-60-2 (HCl)

Description: Brovanexine is an expectorant possessing both the secretagogic action selectively on SG and a mucolytic action toward acid glycoproteins in granules of secretory cells.

Chemical Structure

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Brovanexine HCl
CAS# 54340-60-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 126622
Name: Brovanexine HCl
CAS#: 54340-60-2 (HCl)
Chemical Formula: C24H29Br2ClN2O4
Exact Mass: 602.02
Molecular Weight: 604.764
Elemental Analysis: C, 47.67; H, 4.83; Br, 26.42; Cl, 5.86; N, 4.63; O, 10.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 54340-60-2 (HCl)   54340-61-3 (free base)  

Synonym: Brovanexine hydrochloride; Brovanexine HCl; 54340-60-2; BR-222;

IUPAC/Chemical Name: 4-((2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)phenyl)carbamoyl)-2-methoxyphenyl acetate hydrochloride

InChi Key: GOPILTWRTSSNPV-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H28Br2N2O4.ClH/c1-15(29)32-21-10-9-16(12-22(21)31-3)24(30)27-23-17(11-18(25)13-20(23)26)14-28(2)19-7-5-4-6-8-19;/h9-13,19H,4-8,14H2,1-3H3,(H,27,30);1H

SMILES Code: Cl.COC1=CC(=CC=C1OC(C)=O)C(=O)NC2=C(CN(C)C3CCCCC3)C=C(Br)C=C2Br

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 604.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Garcia-Rafanell J, Lleonart F. [Physicochemical characteristics of the tracheobronchial mucous secretion of lambs. Modification by a new mucolytic agent (Brovanexine UR-389)]. Therapie. 1976 Jul-Aug;31(4):483-90. French. PubMed PMID: 12589.

2: Takeda H, Shimoyama K, Misawa M, Yanaura S, Yamazaki M, Kubo S. [Changes in secretory activity of tracheal submucosal glands by repeated treatment with brovanexine and BR-227 in rats]. Nihon Yakurigaku Zasshi. 1984 Aug;84(2):251-7. Japanese. PubMed PMID: 6489870.

3: Yamazaki M, Shimo T, Tanaka K, Kubo S, Ito Y, Yanaura S, Takeda H. [Sequential changes of the activities of the dog tracheal secretory cells caused by intraduodenal application of brovanexine]. Nihon Yakurigaku Zasshi. 1983 Jul;82(1):57-66. Japanese. PubMed PMID: 6618349.

4: Kasé Y, Hidaka T, Miyata T, Takahama K, Okano Y, Kubo S, Yamazaki M. [Pharmacological effects of brovanexine hydrochloride (BR-222) on the respiratory tract system, particularly on the respiratory tract fluid, mucociliary transport and cough]. Nihon Yakurigaku Zasshi. 1984 Feb;83(2):173-81. Japanese. PubMed PMID: 6745807.

5: Takeda H, Kasamatsu S, Misawa M, Yanaura S. [Effect of brovanexine on secretory activities of tracheal secretory cells]. Nihon Yakurigaku Zasshi. 1983 Jan;81(1):29-37. Japanese. PubMed PMID: 6852680.

6: García-Rafanell J, Bellés L, Morell J. [Increase of rabbit tracheo-nasal mucus secretion by a new mucolytic agent: brovanexine (UR-389) (author's transl)]. Arch Farmacol Toxicol. 1976 Apr;2(1):61-8. Spanish. PubMed PMID: 1275572.

7: Rimbau V, Torralba A. [Pharmacokinetic and distribution studies in rats and mice of 14C-brovanexine (author's transl)]. Arch Farmacol Toxicol. 1978 Aug;4(2):253-60. Spanish. PubMed PMID: 727838.

8: Unakami S, Komoda T, Watanabe M, Tanimoto Y, Sakagishi Y, Ikezawa H. Molecular nature of three liver alkaline phosphatases detected by drug administration in vivo: differences between soluble and membranous enzymes. Comp Biochem Physiol B. 1987;88(1):111-8. PubMed PMID: 2824118.