CPP-115 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125926

CAS#: 760947-97-5 (HCl)

Description: CPP-115 is a GABA-aminotransferase inhibitor potentially for the treatment of infantile spasms and refractory complex partial seizures. CPP-115 is a high-affinity vigabatrin analogue developed to increase therapeutic potency and to limit retinal toxicity.


Chemical Structure

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CPP-115 HCl
CAS# 760947-97-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 125926
Name: CPP-115 HCl
CAS#: 760947-97-5 (HCl)
Chemical Formula: C7H10ClF2NO2
Exact Mass: 213.04
Molecular Weight: 213.609
Elemental Analysis: C, 39.36; H, 4.72; Cl, 16.60; F, 17.79; N, 6.56; O, 14.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 640897-20-7 (free base)   760947-97-5 (HCl)  

Synonym: CPP-115; CPP115; CPP 115; CPP-115 HCl;

IUPAC/Chemical Name: (1S,3S)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid hydrochloride

InChi Key: PGVAKHBXGXBOSB-WINKWTMZSA-N

InChi Code: InChI=1S/C7H9F2NO2.ClH/c8-6(9)4-1-3(7(11)12)2-5(4)10;/h3,5H,1-2,10H2,(H,11,12);1H/t3-,5-;/m0./s1

SMILES Code: Cl.N[C@H]1C[C@H](CC1=C(F)F)C(O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 213.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lee H, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB. Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115). J Am Chem Soc. 2015 Feb 25;137(7):2628-40. doi: 10.1021/ja512299n. PubMed PMID: 25616005; PubMed Central PMCID: PMC4353033.

2: Briggs SW, Mowrey W, Hall CB, Galanopoulou AS. CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms. Epilepsia. 2014 Jan;55(1):94-102. doi: 10.1111/epi.12424. PubMed PMID: 24321005; PubMed Central PMCID: PMC4102583.

3: Doumlele K, Conway E, Hedlund J, Tolete P, Devinsky O. A case report on the efficacy of vigabatrin analogue (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115) in a patient with infantile spasms. Epilepsy Behav Case Rep. 2016 Aug 21;6:67-9. doi: 10.1016/j.ebcr.2016.08.002. PubMed PMID: 27668180; PubMed Central PMCID: PMC5024311.

4: Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, Silverman RB. (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. J Med Chem. 2012 Jan 12;55(1):357-66. doi: 10.1021/jm201231w. PubMed PMID: 22128851; PubMed Central PMCID: PMC3257419.

5: Silverman RB. The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms. J Med Chem. 2012 Jan 26;55(2):567-75. doi: 10.1021/jm201650r. PubMed PMID: 22168767; PubMed Central PMCID: PMC3266980.

6: Lee H, Le HV, Wu R, Doud E, Sanishvili R, Kellie JF, Compton PD, Pachaiyappan B, Liu D, Kelleher NL, Silverman RB. Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. ACS Chem Biol. 2015 Sep 18;10(9):2087-98. doi: 10.1021/acschembio.5b00212. PubMed PMID: 26110556; PubMed Central PMCID: PMC4575653.

7: Yuan H, Silverman RB. Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1651-4. PubMed PMID: 17267220; PubMed Central PMCID: PMC1853296.

8: Cid J, Escolar G, Galan A, López-Vilchez I, Molina P, Díaz-Ricart M, Lozano M, Dumont LJ. In vitro evaluation of the hemostatic effectiveness of cryopreserved platelets. Transfusion. 2016 Mar;56(3):580-6. doi: 10.1111/trf.13371. PubMed PMID: 26450525.

9: Buccellati C, Rossoni G, Bonazzi A, Berti F, Maclouf J, Folco G, Sala A. Nitric oxide modulation of transcellular biosynthesis of cys-leukotrienes in rabbit leukocyte-perfused heart. Br J Pharmacol. 1997 Mar;120(6):1128-34. PubMed PMID: 9134226; PubMed Central PMCID: PMC1564560.