Sulfo-NHS-Acetate sodium
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MedKoo CAT#: 125874

CAS#: 221222-61-3 (sodium)

Description: Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker.

Chemical Structure

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Sulfo-NHS-Acetate sodium
CAS# 221222-61-3 (sodium)
Instruction

Theoretical Analysis

MedKoo Cat#: 125874
Name: Sulfo-NHS-Acetate sodium
CAS#: 221222-61-3 (sodium)
Chemical Formula: C6H6NNaO7S
Exact Mass: 258.98
Molecular Weight: 259.164
Elemental Analysis: C, 27.81; H, 2.33; N, 5.40; Na, 8.87; O, 43.21; S, 12.37

Price and Availability

Size Price Availability Quantity
1mg USD 350 2 Weeks
5mg USD 550 2 Weeks
10mg USD 850 2 Weeks
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Related CAS #: 152305-87-8 (free base)   221222-61-3 (sodium)  

Synonym: Sulfo-NHS-Acetate sodium; Sulfo-nhs-acetate; Sulfosuccinimidyl acetate; Sulfo-NHS-Acetate (sodium)

IUPAC/Chemical Name: sodium 1-acetoxy-2,5-dioxopyrrolidine-3-sulfonate

InChi Key: VGYOVKDAMGIIJU-UHFFFAOYSA-M

InChi Code: InChI=1S/C6H7NO7S.Na/c1-3(8)14-7-5(9)2-4(6(7)10)15(11,12)13;/h4H,2H2,1H3,(H,11,12,13);/q;+1/p-1

SMILES Code: CC(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 259.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Prentice BM, Stutzman JR, McLuckey SA. Reagent cluster anions for multiple gas-phase covalent modifications of peptide and protein cations. J Am Soc Mass Spectrom. 2013 Jul;24(7):1045-52. doi: 10.1007/s13361-013-0637-6. Epub 2013 May 24. PubMed PMID: 23702708; PubMed Central PMCID: PMC3715118.

2: Lai TS, Davies C, Greenberg CS. Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation. Protein Sci. 2010 Feb;19(2):229-35. doi: 10.1002/pro.301. PubMed PMID: 19998405; PubMed Central PMCID: PMC2865712.

3: Becker D, Valk E, Zahn S, Brand P, Knop J. Coupling of contact sensitizers to thiol groups is a key event for the activation of monocytes and monocyte-derived dendritic cells. J Invest Dermatol. 2003 Feb;120(2):233-8. PubMed PMID: 12542528.

4: Guo X, Bandyopadhyay P, Schilling B, Young MM, Fujii N, Aynechi T, Guy RK, Kuntz ID, Gibson BW. Partial acetylation of lysine residues improves intraprotein cross-linking. Anal Chem. 2008 Feb 15;80(4):951-60. doi: 10.1021/ac701636w. Epub 2008 Jan 18. PubMed PMID: 18201069.