Posovolone
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MedKoo CAT#: 465954

CAS#: 256955-84-7 (free base)

Description: Posovolone, also known as Co 134444, is a GABAA receptor positive allosteric modulator. It is also an antidepressant. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.

Chemical Structure

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Posovolone
CAS# 256955-84-7 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 465954
Name: Posovolone
CAS#: 256955-84-7 (free base)
Chemical Formula: C26H40N2O3
Exact Mass: 428.30
Molecular Weight: 428.617
Elemental Analysis: C, 72.86; H, 9.41; N, 6.54; O, 11.20

Price and Availability

Size Price Availability Quantity
25mg USD 750 2 Weeks
50mg USD 1250 2 Weeks
100mg USD 1950 2 Weeks
200mg USD 2950 2 Weeks
500mg USD 4250 2 Weeks
1g USD 5950 2 Weeks
2g USD 8950 2 Weeks
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Related CAS #: 2487231-94-5 (citrate)   256955-84-7 (free base)  

Synonym: Posovolone; CO-134444; CO-134444; CO134444;

IUPAC/Chemical Name: 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3-(methoxymethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-(1H-imidazol-1-yl)ethan-1-one

InChi Key: BRVGKZNQWCQKTC-MVCIVNJCSA-N

InChi Code: InChI=1S/C26H40N2O3/c1-24-10-11-26(30,16-31-3)14-18(24)4-5-19-20-6-7-22(25(20,2)9-8-21(19)24)23(29)15-28-13-12-27-17-28/h12-13,17-22,30H,4-11,14-16H2,1-3H3/t18-,19-,20-,21-,22+,24-,25-,26+/m0/s1

SMILES Code: C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(CN5C=CN=C5)=O)([H])C[C@](COC)(O)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 428.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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