VU6028418

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 465271

CAS#: 2649803-05-2

Description: VU6028418 is a Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor (mAChR) Antagonist. VU6028418 was subsequently evaluated as a preclinical candidate for the treatment of dystonia and other movement disorders.


Chemical Structure

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VU6028418
CAS# 2649803-05-2

Theoretical Analysis

MedKoo Cat#: 465271
Name: VU6028418
CAS#: 2649803-05-2
Chemical Formula: C23H27F3N4O
Exact Mass: 432.21
Molecular Weight: 432.491
Elemental Analysis: C, 63.87; H, 6.29; F, 13.18; N, 12.95; O, 3.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: VU6028418; VU 6028418; VU-6028418;

IUPAC/Chemical Name: (3aR,5s,6aS)-2-((tetrahydro-2H-pyran-4-yl)methyl)-N-(6-(2,3,5-trifluorophenyl)pyridazin-3-yl)octahydrocyclopenta[c]pyrrol-5-amine

InChi Key: ITSKPCHXUYILTR-VQFNDLOPSA-N

InChi Code: InChI=1S/C23H27F3N4O/c24-17-9-19(23(26)20(25)10-17)21-1-2-22(29-28-21)27-18-7-15-12-30(13-16(15)8-18)11-14-3-5-31-6-4-14/h1-2,9-10,14-16,18H,3-8,11-13H2,(H,27,29)/t15-,16+,18+

SMILES Code: FC1=CC(F)=C(F)C(C2=CC=C(N[C@H]3C[C@@](CN(C([H])([H])C4CCOCC4)C5)([H])[C@@]5([H])C3)N=N2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: May 7, 2024- Product VU6028418 Patent licensing News MedKoo is excited to announce the licensing of patents of the novel compound VU6028418 from Vanderbilt University. VU6028418, a breakthrough compound, is now featured on our website at https://www.medkoo.com/products/48056. VU6028418 is a Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor (mAChR) Antagonist. VU6028418 was subsequently evaluated as a preclinical candidate for the treatment of dystonia and other movement disorders. . This groundbreaking product is safeguarded by patents including WO 2021/119265 A1.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 432.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Suwa A, Konishi Y, Uruno Y, Takai K, Nakako T, Sakai M, Enomoto T, Ochi Y, Matsuda H, Kitamura A, Uematsu Y, Kiyoshi A, Sumiyoshi T. Discovery of N-sulfonyl-7-azaindoline derivatives as potent, orally available and selective M(4) muscarinic acetylcholine receptor agonists. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2909-12. doi: 10.1016/j.bmcl.2014.04.083. Epub 2014 May 9. PMID: 24852118.