EXP-561 monohydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414175

CAS#: 16142-83-9 (monohydrate)

Description: EXP-561 monohydrate is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine.

Chemical Structure

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EXP-561 monohydrate
CAS# 16142-83-9 (monohydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 414175
Name: EXP-561 monohydrate
CAS#: 16142-83-9 (monohydrate)
Chemical Formula: C14H22ClNO
Exact Mass: 0.00
Molecular Weight: 255.790
Elemental Analysis: C, 65.74; H, 8.67; Cl, 13.86; N, 5.48; O, 6.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 10207-08-6 (free base)   16142-83-9 (monohydrate)  

Synonym: EXP-561 monohydrate

IUPAC/Chemical Name: 4-Phenylbicyclo(2.2.2)octan-1-amine hydrochloride monohydrate

InChi Key: NLXFYKZUFJZKCP-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19N.ClH.H2O/c15-14-9-6-13(7-10-14,8-11-14)12-4-2-1-3-5-12;;/h1-5H,6-11,15H2;1H;1H2

SMILES Code: NC1(CC2)CCC2(C3=CC=CC=C3)CC1.[H]Cl.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 255.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maj J, Skuza G, Sowińska H, Nowak G. Pharmacological properties of EXP 561, a potential antidepressant drug. J Neural Transm. 1987;70(1-2):81-97. doi: 10.1007/BF01252511. PMID: 2822850.

2: Fuller RW, Snoddy HD. Effects of pre- and post-treatment with EXP 561 on the amine-depleting effects of p-chloroamphetamine and 6-hydroxydopamine in rats. Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):457-65. PMID: 705024.

3: Gershon S, Hekimian LJ, Floyd A. Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561). Arzneimittelforschung. 1968 Feb;18(2):243-5. PMID: 5695389.

4: Koe BK. Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J Pharmacol Exp Ther. 1976 Dec;199(3):649-61. PMID: 994022.

5: Lehmann HE, Ban TA, Debow SL. A clinical-pharmacological study with EXP 561. Curr Ther Res Clin Exp. 1967 Jun;9(6):306-8. PMID: 4963065.

6: Robertson DW, Jones ND, Swartzendruber JK, Yang KS, Wong DT. Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor. J Med Chem. 1988 Jan;31(1):185-9. doi: 10.1021/jm00396a030. PMID: 3257267.

7: Fuller RW, Robertson DW, Hemrick-Luecke SK. Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain. J Pharmacol Exp Ther. 1987 Feb;240(2):415-20. PMID: 3100775.

8: Fuller RW, Hemrick-Luecke SK, Perry KW. Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. J Pharmacol Exp Ther. 1988 Nov;247(2):531-5. PMID: 3141609.

9: Fuller RW, Hemrick-Luecke SK, Robertson DW. Comparison of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) effects on mouse heart norepinephrine. Biochem Pharmacol. 1988 Sep 1;37(17):3343-7. doi: 10.1016/0006-2952(88)90648-x. PMID: 3135812.

10: Fuller RW, Snoddy HD, Molloy BB. Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors. Psychopharmacol Commun. 1975;1(5):455-64. PMID: 1228825.