Diflucortolone (free base)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413729

CAS#: 2607-06-9 (free base)

Description: Diflucortolone (free base) is a topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate.

Chemical Structure

img
Diflucortolone (free base)
CAS# 2607-06-9 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 413729
Name: Diflucortolone (free base)
CAS#: 2607-06-9 (free base)
Chemical Formula: C22H28F2O4
Exact Mass: 394.20
Molecular Weight: 394.460
Elemental Analysis: C, 66.99; H, 7.16; F, 9.63; O, 16.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 15845-96-2 (pivalate)   2607-06-9 (free base)   59198-70-8 (valerate)  

Synonym: Diflucortolone (free base); Diflucortolona; Diflucortolonum

IUPAC/Chemical Name: Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

InChi Key: OGPWIDANBSLJPC-RFPWEZLHSA-N

InChi Code: InChI=1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1

SMILES Code: C[C@@]12[C@@H](C(CO)=O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 394.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hoppe G. Diflucortolone valerate. Asian experience. Drugs. 1988;36 Suppl 5:24-33. doi: 10.2165/00003495-198800365-00006. PMID: 3254827.

2: Veraldi S, Schianchi R, Esposito L, Pontini P, Nazzaro G. Treatment of postscabies prurigo with diflucortolone and chlorquinaldol in a group of African refugees. Trop Doct. 2019 Oct;49(4):268-270. doi: 10.1177/0049475519855577. Epub 2019 Jun 18. PMID: 31208292.

3: Veraldi S, Schianchi R, Pontini P, Gorani A. The association of isoconazole- diflucortolone in the treatment of pediatric tinea corporis. J Dermatolog Treat. 2018 Mar;29(2):200-201. doi: 10.1080/09546634.2017.1360988. Epub 2017 Sep 19. PMID: 28753055.

4: Cabras M, Gambino A, Broccoletti R, Lodi G, Arduino PG. Treatment of angular cheilitis: A narrative review and authors' clinical experience. Oral Dis. 2019 Aug 29. doi: 10.1111/odi.13183. Epub ahead of print. PMID: 31464357.

5: Haviv R, Capua M, Amir J, Harel L. Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature. Pediatr Rheumatol Online J. 2014 Oct 10;12:46. doi: 10.1186/1546-0096-12-46. PMID: 25328491; PMCID: PMC4200200.

6: Brunner N, Yawalkar S. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus. J Am Acad Dermatol. 1991 Dec;25(6 Pt 2):1160-3. doi: 10.1016/0190-9622(91)70317-u. PMID: 1757609.

7: Geraldez MC, Carreon-Gavino M, Hoppe G, Costales A. Diflucortolone valerate ointment with and without occlusion in lichen simplex chronicus. Int J Dermatol. 1989 Nov;28(9):603-4. doi: 10.1111/j.1365-4362.1989.tb02538.x. PMID: 2583907.

8: Abdel-Salam FS, Mahmoud AA, Ammar HO, Elkheshen SA. Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. J Liposome Res. 2017 Mar;27(1):41-55. doi: 10.3109/08982104.2016.1149866. Epub 2016 Mar 9. PMID: 26956098.

9: Czaika VA. Superficial dermatomycoses worldwide: multinational treatment experience with a combination of isoconazole nitrate and diflucortolone valerate. Introduction. Mycoses. 2008 Sep;51 Suppl 4:1. doi: 10.1111/j.1439-0507.2008.01604.x. PMID: 18783558.

10: Täuber U, Weiss C, Matthes H. Does salicylic acid increase the percutaneous absorption of diflucortolone-21-valerate? Skin Pharmacol. 1993;6(4):276-81. doi: 10.1159/000211150. PMID: 8198813.