Diclazuril Na

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MedKoo CAT#: 413701

CAS#: 112209-99-1 (Na)

Description: Diclazuril Na is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed.

Chemical Structure

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Diclazuril Na
CAS# 112209-99-1 (Na)
Instruction

Theoretical Analysis

MedKoo Cat#: 413701
Name: Diclazuril Na
CAS#: 112209-99-1 (Na)
Chemical Formula: C17H8Cl3N4NaO2
Exact Mass: 427.96
Molecular Weight: 429.620
Elemental Analysis: C, 47.53; H, 1.88; Cl, 24.75; N, 13.04; Na, 5.35; O, 7.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 112209-98-0 (K)   101831-37-2 (free base)   112209-99-1 (Na)  

Synonym: Diclazuril Na; Sodium diclazuril; Diclazuril sodium

IUPAC/Chemical Name: Benzeneacetonitrile, 2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-, sodium salt (1:1)

InChi Key: HMGDHGGCYNUBOJ-UHFFFAOYSA-M

InChi Code: InChI=1S/C17H9Cl3N4O2.Na/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24;/h1-6,8,12H,(H,23,25,26);/q;+1/p-1

SMILES Code: N#CC(C1=CC=C(Cl)C=C1)C2=C(Cl)C=C(N(C([N-]3)=O)N=CC3=O)C=C2Cl.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Huang Z, Guo D, Fan J, Zhong Y, Zhang M, He L, Zhang W. HPLC semi-preparative separation of diclazuril enantiomers and racemization in solution. J Sep Sci. 2020 Apr;43(7):1240-1247. doi: 10.1002/jssc.201901201. Epub 2020 Jan 15. PMID: 31909564.

2: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Kolar B, Kouba M, López Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Brantom P, Halle I, van Beelen P, Holczknecht O, Vettori MV, Gropp J. Safety and efficacy of Coxiril® (diclazuril) for chickens reared for laying. EFSA J. 2018 Mar 29;16(3):e05195. doi: 10.2903/j.efsa.2018.5195. PMID: 32625831; PMCID: PMC7009511.

3: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Kolar B, Kouba M, López-Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Brantom P, Halle I, van Beelen P, Holczknecht O, Vettori MV, Gropp J. Safety and efficacy of Coxiril® (diclazuril) for pheasants. EFSA J. 2018 Mar 22;16(3):e05196. doi: 10.2903/j.efsa.2018.5196. PMID: 32625832; PMCID: PMC7009574.

4: El-Ashram S, Aboelhadid SM, Arafa WM, Gadelhaq SM, Abdel-Razik AH. Protective potential of diclazuril-treated oocysts against coccidiosis in layer chicks. Vet Parasitol. 2019 Sep;273:105-111. doi: 10.1016/j.vetpar.2019.08.010. Epub 2019 Aug 20. PMID: 31473449.

5: Wang Z, Wu X, Liu L, Xu L, Kuang H, Xu C. Rapid and sensitive detection of diclazuril in chicken samples using a gold nanoparticle-based lateral-flow strip. Food Chem. 2020 May 15;312:126116. doi: 10.1016/j.foodchem.2019.126116. Epub 2019 Dec 26. PMID: 31901821.

6: Zhang M, Qiu J, Li X, Zhang W, Fan J, Zhou H, He L. Determination of residual enantiomers of diclazuril in chicken edible tissues by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jun 15;1118-1119:203-209. doi: 10.1016/j.jchromb.2019.04.042. Epub 2019 Apr 22. PMID: 31059927.

7: Zhou BH, Ding HY, Yang JY, Chai J, Guo HW, Wang HW. Effects of diclazuril on the expression of enolase in second-generation merozoites of Eimeria tenella. Poult Sci. 2020 Dec;99(12):6402-6409. doi: 10.1016/j.psj.2020.09.068. Epub 2020 Oct 7. PMID: 33248555; PMCID: PMC7705050.

8: El-Sawah AA, Aboelhadid SM, El-Nahass EN, Helal HE, Korany AM, El-Ashram S. Efficacy of probiotic Enterococcus faecium in combination with diclazuril against coccidiosis in experimentally infected broilers. J Appl Microbiol. 2020 Oct;129(4):1020-1028. doi: 10.1111/jam.14691. Epub 2020 May 26. PMID: 32364304.

9: Hunyadi L, Papich MG, Pusterla N. Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days. Vet J. 2018 Dec;242:74-76. doi: 10.1016/j.tvjl.2018.10.009. Epub 2018 Nov 8. PMID: 30503548.

10: Dirikolu L, Lehner F, Nattrass C, Bentz BG, Woods WE, Carter WG, Karpiesiuk W, Jacobs J, Boyles J, Harkins JD, Granstrom DE, Tobin T. Diclazuril in the horse: its identification and detection and preliminary pharmacokinetics. J Vet Pharmacol Ther. 1999 Dec;22(6):374-9. doi: 10.1046/j.1365-2885.1999.00232.x. PMID: 10651466.