Thiopropazate HCl | CAS# 146-28-1 (HCl) | antipsychotic

Thiopropazate HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413474

CAS#: 146-28-1 (HCl)

Description: Thiopropazate HCl is the salt form of Thiopropazate Free Base, a typical antipsychotic of the phenothiazine class. It is a prodrug to perphenazine.

Chemical Structure

Thiopropazate HCl

CAS# 146-28-1 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 413474
Name: Thiopropazate HCl
CAS#: 146-28-1 (HCl)
Chemical Formula: C23H30Cl3N3O2S
Exact Mass: 517.11
Molecular Weight: 518.920
Elemental Analysis: C, 53.24; H, 5.83; Cl, 20.49; N, 8.10; O, 6.17; S, 6.18

Price and Availability

Size	Price	Availability
5mg	USD 240	2 Weeks
10mg	USD 400	2 Weeks
25mg	USD 690	2 Weeks
50mg	USD 1100	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 146-28-1 (HCl) 84-06-0 (free base)

Synonym: Thiopropazate HCl; Thiopropazate hydrochloride; EINECS 205-666-8

IUPAC/Chemical Name: 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, acetate (ester), dihydrochloride

InChi Key: DRLLEHPFGRESBT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H28ClN3O2S.2ClH/c1-18(28)29-16-15-26-13-11-25(12-14-26)9-4-10-27-20-5-2-3-6-22(20)30-23-8-7-19(24)17-21(23)27;;/h2-3,5-8,17H,4,9-16H2,1H3;2*1H

SMILES Code: ClC(C=C1N2CCCN3CCN(CCOC(C)=O)CC3)=CC=C1SC4=C2C=CC=C4.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	To be determined	0.0	100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 518.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bhidayasiri R, Fahn S, Weiner WJ, Gronseth GS, Sullivan KL, Zesiewicz TA; American Academy of Neurology. Evidence-based guideline: treatment of tardive syndromes: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013 Jul 30;81(5):463-9. doi: 10.1212/WNL.0b013e31829d86b6. Erratum in: Neurology. 2013 Nov 26;81(22):1968. PMID: 23897874.

2: Singer K, Cheng MN. Thiopropazate hydrochloride in persistent dyskinesia. Br Med J. 1971 Dec 4;4(5787):626. doi: 10.1136/bmj.4.5787.626-c. PMID: 5167074; PMCID: PMC1799903.

3: DARLING HF. Acetophenazine (Tindal) and thiopropazate (Dartal) in ambulatory psychoneurotic patients. Am J Psychiatry. 1961 Oct;118:358-9. doi: 10.1176/ajp.118.4.358. PMID: 13883575.

4: McLellan DL, Chalmers RJ, Johnson RH. A double-blind trial of tetrabenazine, thiopropazate, and placebo in patients with chorea. Lancet. 1974 Jan 26;1(7848):104-7. doi: 10.1016/s0140-6736(74)92338-1. PMID: 4130307.

5: DOBKIN AB, PURKIN N. The antisialogogue effect of phenothiazine derivatives: comparison of pecazine, perphenazine, fluphenazine, thiopropazate, pipamazine and triflupromazine. Br J Anaesth. 1960 Feb;32:57-9. doi: 10.1093/bja/32.2.57. PMID: 13817061.

6: SCHAUMANN W, KURBJUWEIT HG. [Modifications of various effects of thiopropazate by a central stimulant]. Arzneimittelforschung. 1961 Apr;11:343-50. German. PMID: 13747321.

7: Singer K, Cheng MN. Thiopropazate hydrochloride in persistent dyskinesia. Br Med J. 1971 Oct 2;4(5778):22-5. doi: 10.1136/bmj.4.5778.22. PMID: 4938244; PMCID: PMC1799164.

8: Kazamatsuri H, Chien C, Cole JO. Treatment of tardive dyskinesia. II. Short- term efficacy of dopamine-blocking agents haloperidol and thiopropazate. Arch Gen Psychiatry. 1972 Jul;27(1):100-3. doi: 10.1001/archpsyc.1972.01750250086012. PMID: 4555826.

9: DOBKIN AB. Potentiation of thiopentone anaesthesia. Comparison of promethazine, chlorpromazine, perphenazine, fluphenazine, thiopropazate, pipamazine and triflupromazine. Br J Anaesth. 1960 Sep;32:424-6. doi: 10.1093/bja/32.9.424. PMID: 13723253.

10: POELDINGER W. [Therapeutic experiences with thiopropazate and with a combination of thiopropazate and chlorphencyclan (Vesitan) in psychiatry]. Praxis. 1962 Jan 18;51:73-8. German. PMID: 14487367.

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