Pantoprazole sulfide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576150

CAS#: 102625-64-9

Description: Pantoprazole sulfide is a 2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of gastroesophageal reflux and peptic ulcer.

Chemical Structure

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Pantoprazole sulfide
CAS# 102625-64-9
Instruction

Theoretical Analysis

MedKoo Cat#: 576150
Name: Pantoprazole sulfide
CAS#: 102625-64-9
Chemical Formula: C16H15F2N3O3S
Exact Mass: 367.08
Molecular Weight: 367.370
Elemental Analysis: C, 52.31; H, 4.12; F, 10.34; N, 11.44; O, 13.07; S, 8.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: H-258/28; Pantoprazole sulfide; Pantoprazole related compound B; Pantoprazole thioether

IUPAC/Chemical Name: 5-Difluoromethoxy-2-(((3,4-dimethoxy-2-pyridyl)methyl)thio)-1H-benzimidazole

InChi Key: UKILEIRWOYBGEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H15F2N3O3S/c1-22-13-5-6-19-12(14(13)23-2)8-25-16-20-10-4-3-9(24-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)

SMILES Code: COc1ccnc(CSc2nc3cc(OC(F)F)ccc3[nH]2)c1OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
To be determined 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 367.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yu L, Sun LN, Zhang XH, Xu YH, Zhang HW, Shen YW, Xie LJ, Wang MF, Jiao HW, Li YQ, Wang YQ, Liu Y. Comparison of the gastric acid inhibition function among lansoprazole, pantoprazole, and their respective stereoisomers in healthy Chinese subjects. Int J Clin Pharmacol Ther. 2019 Aug 9. doi: 10.5414/CP203514. [Epub ahead of print] PubMed PMID: 31397275.

2: Albatany M, Ostapchenko VG, Meakin S, Bartha R. Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms. J Neurooncol. 2019 Aug 7. doi: 10.1007/s11060-019-03251-7. [Epub ahead of print] PubMed PMID: 31392597.

3: Tharmalingam N, Khader R, Fuchs BB, Mylonakis E. The Anti-virulence Efficacy of 4-(1,3-Dimethyl-2,3-Dihydro-1H-Benzimidazol-2-yl)Phenol Against Methicillin-Resistant Staphylococcus aureus. Front Microbiol. 2019 Jul 17;10:1557. doi: 10.3389/fmicb.2019.01557. eCollection 2019. PubMed PMID: 31379761; PubMed Central PMCID: PMC6653400.

4: Ying J, Li LC, Wu CY, Yu ZW, Kan LD. The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China. Rev Esp Enferm Dig. 2019 Aug 2;111. doi: 10.17235/reed.2019.6155/2019. [Epub ahead of print] PubMed PMID: 31373505.

5: Madi L, Ahmed Elhada AH, Alrawashdeh H, Ahmed A. Prescribing Pattern of Proton Pump Inhibitors in Qatar Rehabilitation Institute: A Retrospective Study. J Res Pharm Pract. 2019 Apr-Jun;8(2):101-104. doi: 10.4103/jrpp.JRPP_18_79. PubMed PMID: 31367645; PubMed Central PMCID: PMC6636417.