Colesevelam HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413231

CAS#: 182815-44-7 (HCl)

Description: Colesevelam HCl is an allylamine derivative that binds BILE ACIDS in the intestine and is used as an ANTICHOLESTEREMIC AGENT in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS.

Chemical Structure

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Colesevelam HCl
CAS# 182815-44-7 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 413231
Name: Colesevelam HCl
CAS#: 182815-44-7 (HCl)
Chemical Formula: C31H67Cl3N4O
Exact Mass: 0.00
Molecular Weight: 618.250
Elemental Analysis: C, 60.22; H, 10.92; Cl, 17.20; N, 9.06; O, 2.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 182815-43-6 (free base)   182815-44-7 (HCl)  

Synonym: Colesevelam HCl; GT31-104HB; GT 31-104HB; GT-31-104HB

IUPAC/Chemical Name: 1-Hexaminium, N,N,N-trimethyl-6-(2-propenylamino)-, chloride, polymer with (chloromethyl)oxirane, 2-propen-4-amine and N-2-propenyl-1-decanamine, hydrochloride

InChi Key: VTAKZNRDSPNOAU-UHFFFAOYSA-M

InChi Code: InChI=1S/C13H27N.C12H27N2.C3H5ClO.C3H7N.2ClH/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4;;/h4,14H,2-3,5-13H2,1H3;5,13H,1,6-12H2,2-4H3;3H,1-2H2;2H,1,3-4H2;2*1H/q;+1;;;;/p-1

SMILES Code: CCCCCCCCCCNCC=C.C[N+](C)(CCCCCCNCC=C)C.NCC=C.ClCC1CO1.Cl.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 618.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Patel PH, Can AS. Colesevelam. 2020 Nov 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 32491747.

2: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Colesevelam. 2017 Sep 28. PMID: 31644180.

3: Melian EB, Plosker GL. Colesevelam. Am J Cardiovasc Drugs. 2001;1(2):141-6; discussion 147-8. doi: 10.2165/00129784-200101020-00007. PMID: 14728043.

4: Nerild HH, Christensen MB, Knop FK, Brønden A. Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes. Expert Opin Drug Discov. 2018 Dec;13(12):1161-1167. doi: 10.1080/17460441.2018.1538206. Epub 2018 Oct 23. PMID: 30336707.

5: Steinmetz KL. Colesevelam hydrochloride. Am J Health Syst Pharm. 2002 May 15;59(10):932-9. doi: 10.1093/ajhp/59.10.932. PMID: 12040732.

6: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Colesevelam. 2018 Oct 31. PMID: 30000454.

7: Kalra S, Priya G, Aggarwal S. Colesevelam in the management of type 2 diabetes. J Pak Med Assoc. 2020 May;70(5):934-936. PMID: 32400758.

8: Robinson DM, Keating GM. Colesevelam: a review of its use in hypercholesterolemia. Am J Cardiovasc Drugs. 2007;7(6):453-65. doi: 10.2165/00129784-200707060-00009. PMID: 18076213.

9: Ooi CP, Loke SC. Colesevelam for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD009361. doi: 10.1002/14651858.CD009361.pub2. PMID: 23235674; PMCID: PMC6486226.

10: Perry CM. Colesevelam: in pediatric patients with heterozygous familial hypercholesterolemia. Paediatr Drugs. 2010 Apr 1;12(2):133-40. doi: 10.2165/11204890-000000000-00000. PMID: 20218749.