Coenzyme A (Li salt)
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MedKoo CAT#: 412708

CAS#: 18439-24-2 (salt)

Description: Coenzyme A (Li salt) is the salt form of Coenzyme A (free acid), a coenzyme containing pantothenic acid, adenosine 3-phosphate 5-pyrophosphate, and cysteamine; involved in the transfer of acyl groups, notably in transacetylations.

Chemical Structure

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Coenzyme A (Li salt)
CAS# 18439-24-2 (salt)
Instruction

Theoretical Analysis

MedKoo Cat#: 412708
Name: Coenzyme A (Li salt)
CAS#: 18439-24-2 (salt)
Chemical Formula: C21H33Li3N7O16P3S
Exact Mass: 785.14
Molecular Weight: 785.300
Elemental Analysis: C, 32.12; H, 4.24; Li, 2.65; N, 12.49; O, 32.60; P, 11.83; S, 4.08

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10mg USD 262 2 Weeks
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Related CAS #: 85-61-0 (free acid)   18439-24-2 (salt)  

Synonym: Coenzyme A (Li salt)

IUPAC/Chemical Name: lithium (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(((((((R)-3-hydroxy-4-((3-((2-mercaptoethyl)amino)-3-oxopropyl)amino)-2,2-dimethyl-4-oxobutoxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)tetrahydrofuran-3-yl hydrogen phosphate

InChi Key: QSCBPHBAFBVXRK-FFKZSOHASA-K

InChi Code: InChI=1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16+,20-;;;/m1.../s1

SMILES Code: O[C@@](C(NCCC(NCCS)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[Li+].[Li+].[Li+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 785.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Qi R, Bai Y, Li K, Liu N, Xu Y, Dal E, Wang Y, Lin R, Wang H, Liu Z, Li X, Wang X, Shi B. Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs. Drug Resist Updat. 2023 May;68:100960. doi: 10.1016/j.drup.2023.100960. Epub 2023 Mar 28. PMID: 37003125.


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5: Zhang Z, Ding B, He H, Wang J, Liu X, Guo J, Li P, Madigosky SR. The effect of bile salt diet supplementation on genes related to fat metabolism in yellow- feathered broilers. Vet World. 2022 Apr;15(4):911-918. doi: 10.14202/vetworld.2022.911-918. Epub 2022 Apr 13. PMID: 35698512; PMCID: PMC9178600.


6: Hao L, Wang S, Zhang Y, Xu C, Yu Y, Xiang L, Huang W, Tian B, Li T, Wang S. Long-distance transport of the pear HMGR1 mRNA via the phloem is associated with enhanced salt tolerance. Plant Sci. 2023 Jul;332:111705. doi: 10.1016/j.plantsci.2023.111705. Epub 2023 Apr 12. PMID: 37059127.


7: Wang C, Hu HJ, Dong QQ, Huang R, Zhao W, Song YJ, Li ZY, Wang N, Zhang TC, Luo XG. Enhancing bile tolerance of Lactobacilli is involved in the hypolipidemic effects of liraglutide. Biosci Biotechnol Biochem. 2021 May 25;85(6):1395-1404. doi: 10.1093/bbb/zbab053. PMID: 33784390.


8: Manzanares-Estreder S, Espí-Bardisa J, Alarcón B, Pascual-Ahuir A, Proft M. Multilayered control of peroxisomal activity upon salt stress in Saccharomyces cerevisiae. Mol Microbiol. 2017 Jun;104(5):851-868. doi: 10.1111/mmi.13669. Epub 2017 Apr 10. PMID: 28321934.


9: Li X, Gu GQ, Chen W, Gao LJ, Wu XH, Zhang LQ. The outer membrane protein OprF and the sigma factor SigX regulate antibiotic production in Pseudomonas fluorescens 2P24. Microbiol Res. 2018 Jan;206:159-167. doi: 10.1016/j.micres.2017.10.006. Epub 2017 Oct 16. PMID: 29146252.


10: Chen K, Li S, Chen F, Li J, Luo X. Regulation of the Lactobacillus Strains on HMGCoA Reductase Gene Transcription in Human HepG2 Cells via Nuclear Factor- κB. J Microbiol Biotechnol. 2016 Feb;26(2):402-7. doi: 10.4014/jmb.1507.07086. PMID: 26528536.


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12: Wang M, Wang Y, Wu H, Xu J, Li T, Hegebarth D, Jetter R, Chen L, Wang Z. Three TaFAR genes function in the biosynthesis of primary alcohols and the response to abiotic stresses in Triticum aestivum. Sci Rep. 2016 Apr 26;6:25008. doi: 10.1038/srep25008. PMID: 27112792; PMCID: PMC4845010.


13: Li C, Yang CW, Park JH, Lim SW, Sun BK, Jung JY, Kim SB, Kim YS, Kim J, Bang BK. Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy. Am J Physiol Renal Physiol. 2004 Jan;286(1):F46-57. doi: 10.1152/ajprenal.00428.2002. Epub 2003 Sep 30. PMID: 14519596.


14: Wen C, Zhang Z, Shi Q, Duan X, Du J, Wu C, Li X. Methyl Jasmonate- and Salicylic Acid-Induced Transcription Factor ZjWRKY18 Regulates Triterpenoid Accumulation and Salt Stress Tolerance in Jujube. Int J Mol Sci. 2023 Feb 15;24(4):3899. doi: 10.3390/ijms24043899. PMID: 36835319; PMCID: PMC9965381.


15: Otani H, Stogios PJ, Xu X, Nocek B, Li SN, Savchenko A, Eltis LD. The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism. Nucleic Acids Res. 2016 Jan 29;44(2):595-607. doi: 10.1093/nar/gkv955. Epub 2015 Sep 22. PMID: 26400178; PMCID: PMC4737184.


16: Zhang H, Zhang S, Li M, Wang J, Wu T. The PoLACS4 Gene May Participate in Drought Stress Resistance in Tree Peony (Paeonia ostii 'Feng Dan Bai'). Genes (Basel). 2022 Sep 5;13(9):1591. doi: 10.3390/genes13091591. PMID: 36140759; PMCID: PMC9498442.


17: Han LQ, Pang K, Li HJ, Zhu SB, Wang LF, Wang YB, Yang GQ, Yang GY. Conjugated linoleic acid-induced milk fat reduction associated with depressed expression of lipogenic genes in lactating Holstein mammary glands. Genet Mol Res. 2012 Sep 17;11(4):4754-64. doi: 10.4238/2012.September.17.2. PMID: 23079976.


18: Allen Maycock CA, Muhlestein JB, Horne BD, Carlquist JF, Bair TL, Pearson RR, Li Q, Anderson JL; Intermountain Heart Collaborative Study. Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients. J Am Coll Cardiol. 2002 Nov 20;40(10):1777-85. doi: 10.1016/s0735-1097(02)02477-4. PMID: 12446061.


19: Zhang CL, Zhang YL, Hu X, Xiao X, Wang GL, You CX, Li YY, Hao YJ. An apple long-chain acyl-CoA synthetase, MdLACS4, induces early flowering and enhances abiotic stress resistance in Arabidopsis. Plant Sci. 2020 Aug;297:110529. doi: 10.1016/j.plantsci.2020.110529. Epub 2020 May 31. PMID: 32563467.


20: Zhang CL, Hu X, Zhang YL, Liu Y, Wang GL, You CX, Li YY, Hao YJ. An apple long-chain acyl-CoA synthetase 2 gene enhances plant resistance to abiotic stress by regulating the accumulation of cuticular wax. Tree Physiol. 2020 Oct 7;40(10):1450-1465. doi: 10.1093/treephys/tpaa079. PMID: 32578855.