10-deacetyl-7-xylosyl Paclitaxel
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MedKoo CAT#: 463566

CAS#: 90332-63-1

Description: 10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T. chinensis. It induces the disassembly of pig brain and Physarum microtubules in cell-free assays. 10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of, as well as induces cell cycle arrest at the G2/M phase and apoptosis in, PC3 prostate cancer cells.


Chemical Structure

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10-deacetyl-7-xylosyl Paclitaxel
CAS# 90332-63-1

Theoretical Analysis

MedKoo Cat#: 463566
Name: 10-deacetyl-7-xylosyl Paclitaxel
CAS#: 90332-63-1
Chemical Formula: C50H57NO17
Exact Mass: 943.3626
Molecular Weight: 943.996
Elemental Analysis: C, 63.62; H, 6.09; N, 1.48; O, 28.81

Price and Availability

Size Price Availability Quantity
5.0mg USD 230.0 2 Weeks
10.0mg USD 370.0 2 Weeks
25.0mg USD 610.0 2 Weeks
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Synonym: 10-deacetyl-7-xylosyl Paclitaxel;

IUPAC/Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

InChi Key: ORKLEZFXASNLFJ-DYLQFHMVSA-N

InChi Code: InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1

SMILES Code: C[C@@]1([C@@]([H])([C@@](CO2)(OC(C)=O)[C@]2(C[C@@H]1O[C@@]([H])([C@H](O)[C@H]3O)OC[C@H]3O)[H])[C@@H]4OC(C5=CC=CC=C5)=O)C([C@H](O)C6=C([C@H](C[C@@]4(C6(C)C)O)OC([C@@H]([C@@H](NC(C7=CC=CC=C7)=O)C8=CC=CC=C8)O)=O)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 943.996 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lataste H, Senilh V, Wright M, Guénard D, Potier P. Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4090-4. doi: 10.1073/pnas.81.13.4090. PMID: 6146136; PMCID: PMC345374.