Quinidine polygalacturonate

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MedKoo CAT#: 412348

CAS#: 27555-34-6 (polygalacturonate)

Description: Quinidine polygalacturonate is used to treat or prevent many types of irregular heartbeats (heart arrhythmias such as atrial fibrillation). Quinidine can greatly improve your ability to perform normal activities by decreasing the number of irregular heartbeats you have.

Chemical Structure

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Quinidine polygalacturonate
CAS# 27555-34-6 (polygalacturonate)
Instruction

Theoretical Analysis

MedKoo Cat#: 412348
Name: Quinidine polygalacturonate
CAS#: 27555-34-6 (polygalacturonate)
Chemical Formula: C26H32N2O9
Exact Mass: 516.21
Molecular Weight: 516.550
Elemental Analysis: C, 60.46; H, 6.24; N, 5.42; O, 27.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 747-45-5 (bisulfate)   27555-34-6 (polygalacturonate)   56-54-2 (free base)   1668-99-1 (HCl)   7054-25-3 (gluconate)  

Synonym: Quinidine polygalacturonate; Cardioquin; Naticardina; Ritmocor

IUPAC/Chemical Name: (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(2S,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid

InChi Key: OPDHRDFWNKFWIN-NUKLETMZSA-N

InChi Code: InChI=1S/C26H32N2O9/c1-3-13-12-28-9-7-14(13)10-19(28)26(36,24(33)22(31)20(29)21(30)23(32)25(34)35)17-6-8-27-18-5-4-15(37-2)11-16(17)18/h3-6,8,11,13-14,19-23,29-32,36H,1,7,9-10,12H2,2H3,(H,34,35)/t13-,14-,19+,20?,21?,22?,23?,26-/m0/s1

SMILES Code: O[C@@]([C@@H]1N(CC2)C[C@H](C=C)[C@]2([H])C1)(C(C(O)C(O)C(O)C(O)C(O)=O)=O)C3=CC=NC4=CC=C(OC)C=C34

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 516.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dahl JR, Ueda CT, Meyers DG, Wulf BG. Comparative bioavailability characteristics of commercial quinidine polygalacturonate and sulfate tablets. DICP. 1990 Jul-Aug;24(7-8):685-8. doi: 10.1177/106002809002400704. PMID: 2375136.

2: Inama G, Durin O, Pedrinazzi C, Berisso MZ, Furlanello F. 'Orphan drugs' in cardiology: nadolol and quinidine. J Cardiovasc Med (Hagerstown). 2010 Feb;11(2):143-4. doi: 10.2459/JCM.0b013e3283313525. PMID: 19829129.

3: GOLDBERG WM, CHAKRABARTI SG. THE RELATIONSHIP OF DOSAGE SCHEDULE TO THE BLOOD LEVEL OF QUINIDINE, USING ALL AVAILABLE QUINIDINE PREPARATIONS. Can Med Assoc J. 1964 Nov 7;91(19):991-6. PMID: 14222674; PMCID: PMC1928075.

4: Frigo GM, Perucca E, Teggia-Droghi M, Gatti G, Mussini A, Salerno J. Comparison of quinidine plasma concentration curves following oral administration of some short- and long-acting formulations. Br J Clin Pharmacol. 1977 Aug;4(4):449-54. doi: 10.1111/j.1365-2125.1977.tb00760.x. PMID: 901736; PMCID: PMC1429058.

5: Soeterboek AM, Van Thiel M, Eng C. Serum quinidine levels after chronic administration of four different quinidine formulations. J Int Med Res. 1976;4(6):393-401. doi: 10.1177/030006057600400604. PMID: 1027633.

6: Normand JP, Legendre M, Kahn JC, Bourdarias JP, Mathivat A. Comparative efficacy of short-acting and long-acting quinidine for maintenance of sinus rhythm after electrical conversion of atrial fibrillation. Br Heart J. 1976 Apr;38(4):381-7. doi: 10.1136/hrt.38.4.381. PMID: 773392; PMCID: PMC483005.

7: FERRARI M, GELATI M, SALVATORE V. [Clinical experience with a new quinidine preparation: quinidine polygalacturonate]. G Clin Med. 1960 Mar;41:309-25. Italian. PMID: 13822401.

8: KHORSANDIAN R, CAPLAN RF, FEINBERG LJ, BELLET S. Plasma quinidine content levels following single oral doses of quinidine polygalacturonate. Am J Med Sci. 1963 Mar;245:311-6. PMID: 14032404.

9: Chimienti M, Regazzi MB, La Rovere MT, Salerno JA, Previtali M, Montericcio V, Rondanelli R, Montemartini C. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2(5):679-86. doi: 10.1007/BF00054209. PMID: 2484920.

10: VARELA DE SEIJAS JR, DE RABAGO P, SANCHEZ-CASCOS A, LUIS D. [Conversion of auricular fibrillation to sinusal rhythm with a new quinidine preparation, quinidine polygalacturonate]. Rev Clin Esp. 1962 Feb 28;84:233-40. Spanish. PMID: 13924825.