Etintidine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535704

CAS#: 71807-56-2 (HCl)

Description: Etintidine hydrochloride is a Histamine H2 Receptor.

Chemical Structure

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Etintidine hydrochloride
CAS# 71807-56-2 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 535704
Name: Etintidine hydrochloride
CAS#: 71807-56-2 (HCl)
Chemical Formula: C12H17ClN6S
Exact Mass: 312.09
Molecular Weight: 312.820
Elemental Analysis: C, 46.08; H, 5.48; Cl, 11.33; N, 26.87; S, 10.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 69539-53-3 (free base)   71807-56-2 (HCl)  

Synonym: Etintidine hydrochloride

IUPAC/Chemical Name: Guanidine, N''-cyano-N-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-N'-2-propynyl-, monohydrochloride

InChi Key: BHEZOMBVJJYAFT-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H16N6S.ClH/c1-3-4-14-12(16-8-13)15-5-6-19-7-11-10(2)17-9-18-11;/h1,9H,4-7H2,2H3,(H,17,18)(H2,14,15,16);1H

SMILES Code: C#CCN/C(NCCSCC1=C(C)NC=N1)=N\C#N.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 312.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cavanagh RL, Usakewicz JJ, Buyniski JP. A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine. J Pharmacol Exp Ther. 1983 Jan;224(1):171-9. PMID: 6129316.


2: Huang SM, Marriott TB, Weintraub HS, Boccagno JA, Abels R. The effect of food or milk on the bioavailability of etintidine in healthy subjects. Int J Clin Pharmacol Ther Toxicol. 1988 Mar;26(3):113-7. PMID: 2900817.


3: Huang SM, Rubin E, Marriott TB. A high-performance liquid chromatographic microassay employing a liquid-solid extraction technique for etintidine in plasma. Pharm Res. 1987 Apr;4(2):133-6. doi: 10.1023/a:1016419019715. PMID: 3509136.


4: Schulz M, Schmoldt A. Interactions of the histamine H2-receptor antagonist etintidine with rat liver cytochrome P-450: a comparison with cimetidine. Naunyn Schmiedebergs Arch Pharmacol. 1987 Oct;336(4):453-8. doi: 10.1007/BF00164882. PMID: 2893298.


5: Müller P, Dammann HG, Simon B. Einmal abendliche Gabe von Etintidin beim Menschen: Wirkung auf Süresekretion und Verhalten wichtiger Hormone [Single evening administration of etintidine in the human: effect on acid secretion and behavior of important hormones]. Z Gastroenterol. 1985 Mar;23(3):115-20. German. PMID: 2867653.


6: Huang SM, Weintraub HS, Marriott TB, Marinan B, Abels R. Etintidine- propranolol interaction study in humans. J Pharmacokinet Biopharm. 1987 Dec;15(6):557-68. doi: 10.1007/BF01068412. PMID: 2897462.


7: Huang SM, Weintraub HS, Marriott TB, Marinan B, Abels R, Leese PT. Etintidine-theophylline interaction study in humans. Biopharm Drug Dispos. 1987 Nov-Dec;8(6):561-9. doi: 10.1002/bdd.2510080607. PMID: 2892545.


8: Dammann HG, Rehner M, Dreyer M, Walter TA, Müller P, Simon B. Wirkung verschiedener Dosierungen des neuen Imidazol-H2-Rezeptorantagonisten Etintidin auf die intragastrale Azidität des Menschen [The action of various doses of the new imidazole H2-receptor antagonist etintidine on intragastric acidity in man]. Arzneimittelforschung. 1986 Nov;36(11):1699-701. German. PMID: 2880596.


9: Scott CK, Katz LB, Shriver DA. Pharmacological profile of etintidine, a new histamine H2-receptor antagonist. Arch Int Pharmacodyn Ther. 1986 May;281(1):5-21. PMID: 2875695.


10: Huang SM, Marriott TB, Weintraub HS, Arnold JD, Boccagno J, Abels R, Harris W. Single-dose and multiple-dose pharmacokinetics of etintidine in healthy volunteers. Eur J Clin Pharmacol. 1988;34(1):101-4. doi: 10.1007/BF01061428. PMID: 2896125.