Stiripentol | CAS#49763-96-4

Stiripentol
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 330238

CAS#: 49763-96-4

Description: Stiripentol (marketed as Diacomit by Laboratoires Biocodex) is an anticonvulsant drug used in the treatment of epilepsy. It is approved for the treatment of Dravet syndrome, an epilepsy syndrome. Stiripentol increases GABAergic activity. At clinically relevant concentrations, it enhances central GABA neurotransmission through a barbiturate-like effect, since it increases the duration of opening of GABA-A receptor channels in hippocampal slices.

Chemical Structure

Stiripentol

CAS# 49763-96-4

Instruction

Theoretical Analysis

MedKoo Cat#: 330238
Name: Stiripentol
CAS#: 49763-96-4
Chemical Formula: C14H18O3
Exact Mass: 234.13
Molecular Weight: 234.295
Elemental Analysis: C, 71.77; H, 7.74; O, 20.49

Price and Availability

Size	Price	Availability
1g	USD 150	2 Weeks
5g	USD 450	2 Weeks
10g	USD 750	2 Weeks
50g	USD 2450	2 Weeks
100g	USD 4450	2 Weeks
200g	USD 7550	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 49763-96-4 137767-55-6 (mixtures of EZ isomers)

Synonym: BCX 2600; BCX-2600; BCX2600; Diacomit; Estiripentol;

IUPAC/Chemical Name: 1-(1,3-Benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol

InChi Key: IBLNKMRFIPWSOY-FNORWQNLSA-N

InChi Code: InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+

SMILES Code: CC(C)(C)C(O)/C=C/C1=CC=C(OCO2)C2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 234.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Available from http://www.ncbi.nlm.nih.gov/books/NBK548951/ PubMed PMID: 31644256.

2: Frampton JE. Stiripentol: A Review in Dravet Syndrome. Drugs. 2019 Nov;79(16):1785-1796. doi: 10.1007/s40265-019-01204-y. Review. PubMed PMID: 31617141.

3: Eschbach K, Knupp KG. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. doi: 10.1080/17512433.2019.1605904. Epub 2019 Apr 24. Review. PubMed PMID: 31017478.

4: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK535603/ PubMed PMID: 30601612.

5: Brigo F, Igwe SC, Bragazzi NL. Stiripentol add-on therapy for focal refractory epilepsy. Cochrane Database Syst Rev. 2018 May 10;5:CD009887. doi: 10.1002/14651858.CD009887.pub4. Review. PubMed PMID: 29747241; PubMed Central PMCID: PMC6494649.

6: Nickels KC, Wirrell EC. Stiripentol in the Management of Epilepsy. CNS Drugs. 2017 May;31(5):405-416. doi: 10.1007/s40263-017-0432-1. Review. PubMed PMID: 28434133.

7: Stiripentol (Diacomit): For Severe Myoclonic Epilepsy in Infancy (Dravet Syndrome) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Apr. Available from http://www.ncbi.nlm.nih.gov/books/NBK349342/ PubMed PMID: 26962599.

8: Chiron C. Stiripentol and vigabatrin current roles in the treatment of epilepsy. Expert Opin Pharmacother. 2016 Jun;17(8):1091-101. doi: 10.1517/14656566.2016.1161026. Epub 2016 Mar 17. Review. PubMed PMID: 26933940.

9: Verrotti A, Prezioso G, Stagi S, Paolino MC, Parisi P. Pharmacological considerations in the use of stiripentol for the treatment of epilepsy. Expert Opin Drug Metab Toxicol. 2016;12(3):345-52. doi: 10.1517/17425255.2016.1145657. Epub 2016 Feb 18. Review. PubMed PMID: 26890312.

10: Brigo F, Storti M, Igwe SC. Stiripentol for focal refractory epilepsy. Cochrane Database Syst Rev. 2015 Oct 21;(10):CD009887. doi: 10.1002/14651858.CD009887.pub3. Review. Update in: Cochrane Database Syst Rev. 2018 May 10;5:CD009887. PubMed PMID: 26488459.

11: Brigo F, Storti M. Stiripentol for focal refractory epilepsy. Cochrane Database Syst Rev. 2014 Jan 31;(1):CD009887. doi: 10.1002/14651858.CD009887.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;(10):CD009887. PubMed PMID: 24488598.

12: Plosker GL. Stiripentol : in severe myoclonic epilepsy of infancy (dravet syndrome). CNS Drugs. 2012 Nov;26(11):993-1001. doi: 10.1007/s40263-012-0004-3. Review. PubMed PMID: 23018548.

13: Verdier MC, Tribut O, Bentué-Ferrer D. [Therapeutic drug monitoring of stiripentol]. Therapie. 2012 Mar-Apr;67(2):157-60. doi: 10.2515/therapie/2012014. Epub 2012 Aug 2. Review. French. PubMed PMID: 22850103.

14: Nabbout R, Chiron C. Stiripentol: an example of antiepileptic drug development in childhood epilepsies. Eur J Paediatr Neurol. 2012 Sep;16 Suppl 1:S13-7. doi: 10.1016/j.ejpn.2012.04.009. Epub 2012 Jun 12. Review. PubMed PMID: 22695038.

15: Fisher JL. The effects of stiripentol on GABA(A) receptors. Epilepsia. 2011 Apr;52 Suppl 2:76-8. doi: 10.1111/j.1528-1167.2011.03008.x. Review. PubMed PMID: 21463286; PubMed Central PMCID: PMC3652007.

16: Chiron C. Stiripentol. Neurotherapeutics. 2007 Jan;4(1):123-5. Review. PubMed PMID: 17199026.

17: Chiron C. Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11. Review. PubMed PMID: 16022579.

18: Trojnar MK, Wojtal K, Trojnar MP, Czuczwar SJ. Stiripentol. A novel antiepileptic drug. Pharmacol Rep. 2005 Mar-Apr;57(2):154-60. Review. PubMed PMID: 15886413.

19: Stiripentol. BCX 2600. Drugs R D. 2002;3(3):220-2. Review. PubMed PMID: 12099174.

20: Bebin M, Bleck TP. New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol. Drugs. 1994 Aug;48(2):153-71. Review. PubMed PMID: 7527321.

Your view history

Stiripentol featured