Oxolamine citrate | CAS# 1949-20-8 | Biochemical

Oxolamine citrate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573954

CAS#: 1949-20-8 (citrate)

Description: Oxolamine citrate is a antiinflammatory drug used as a cough suppressant.

Chemical Structure

Oxolamine citrate

CAS# 1949-20-8 (citrate)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 573954
Name: Oxolamine citrate
CAS#: 1949-20-8 (citrate)
Chemical Formula: C20H27N3O8
Exact Mass: 437.18
Molecular Weight: 437.449
Elemental Analysis: C, 54.91; H, 6.22; N, 9.61; O, 29.26

Price and Availability

Size	Price	Availability	Quantity
25g	USD 450	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1219-20-1 (HCl) 1949-20-8 (citrate) 959-14-8

Synonym: AF 438, AF438, AF-438, Oxolamine citrate, Oxolamine dihydrogen citrate

IUPAC/Chemical Name: 1,2,4-Oxadiazole, 5-(2-(diethylamino)ethyl)-3-phenyl-, citrate

InChi Key: RBZIGQJSMCOHSS-UHFFFAOYSA-N

InChi Code: 1S/C14H19N3O.C6H8O7/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-9H,3-4,10-11H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code: c1(c2ccccc2)nc(CC[NH+](CC)CC)on1.C([C@@](CC(=O)[O-])(C(O)=O)O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Oxolamine citrate is a antiinflammatory drug used as a cough suppressant.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	93.5	213.74
	Water	28.7	65.48

Preparing Stock Solutions

The following data is based on the product molecular weight 437.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Wang XQ, Wang XM, Zhou TF, Dong LQ. Screening of differentially expressed genes and small molecule drugs of pediatric allergic asthma with DNA microarray. Eur Rev Med Pharmacol Sci. 2012 Dec;16(14):1961-6. PubMed PMID: 23242723.

2: Zhu X, Lee DY, Shin WG. Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharm Drug Dispos. 2007 Apr;28(3):125-33. PubMed PMID: 17295362.

3: Min KA, Zhu X, Oh JM, Shin WG. Effect of oxolamine on anticoagulant effect of warfarin. Am J Health Syst Pharm. 2006 Jan 15;63(2):153-6. PubMed PMID: 16390929.

4: Ceyhan BB, Karakurt S. Effect of oxolamine on cough sensitivity in COPD patients. Respir Med. 2002 Jan;96(1):61-3. PubMed PMID: 11863211.

5: Kirilmaz L, Kendirci A, Güneri T. Sustained-release dosage form of oxolamine citrate: preparation and release kinetics. J Microencapsul. 1992 Apr-Jun;9(2):167-72. PubMed PMID: 1593399.

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