NLG802 HCl

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MedKoo CAT#: 207064

CAS#: 2071684-09-6 (HCl)

Description: NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).

Chemical Structure

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NLG802 HCl
CAS# 2071684-09-6 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 207064
Name: NLG802 HCl
CAS#: 2071684-09-6 (HCl)
Chemical Formula: C18H26ClN3O3
Exact Mass: 0.00
Molecular Weight: 367.874
Elemental Analysis: C, 58.77; H, 7.12; Cl, 9.64; N, 11.42; O, 13.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 2071684-08-5 (free base)   2071684-09-6 (HCl)    

Synonym: NLG802; NLG-802; NLG 802; NLG802 HCl;

IUPAC/Chemical Name: Na-(L-leucyl)-1-methyl-D-tryptophan hydrochloride

InChi Key: AUVNEVXWZKBPCE-LDXVYITESA-N

InChi Code: InChI=1S/C18H25N3O3.ClH/c1-11(2)8-14(19)17(22)20-15(18(23)24)9-12-10-21(3)16-7-5-4-6-13(12)16;/h4-7,10-11,14-15H,8-9,19H2,1-3H3,(H,20,22)(H,23,24);1H/t14-,15+;/m0./s1

SMILES Code: O=C(O)[C@@H](CC1=CN(C)C2=C1C=CC=C2)NC([C@H](CC(C)C)N)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against IDO1-expressing tumor cells, thereby inhibiting their growth. IDO1, overexpressed by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the immune system. NLG802 elicits increased plasma concentrations of indoximod and improves its efficacy, compared to the direct administration of indoximod.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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