Lysyllysyllysine acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530707

CAS#: 79360-13-7

Description: Lysyllysyllysine acetate is a bioactive chemical.

Chemical Structure

img
Lysyllysyllysine acetate
CAS# 79360-13-7
Instruction

Theoretical Analysis

MedKoo Cat#: 530707
Name: Lysyllysyllysine acetate
CAS#: 79360-13-7
Chemical Formula: C26H54N6O12
Exact Mass: 642.38
Molecular Weight: 642.748
Elemental Analysis: C, 48.59; H, 8.47; N, 13.08; O, 29.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lysyllysyllysine acetate

IUPAC/Chemical Name: L-Lysyl-L-lysyl-L-lysine tetraacetate

InChi Key: JAVDPFYWWKGGGD-XKPIFEAVSA-N

InChi Code: InChI=1S/C18H38N6O4.4C2H4O2/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21;4*1-2(3)4/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28);4*1H3,(H,3,4)/t13-,14-,15-;;;;/m0..../s1

SMILES Code: NCCCC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCCN)N)=O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 642.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Schilter H, Findlay AD, Perryman L, Yow TT, Moses J, Zahoor A, Turner CI, Deodhar M, Foot JS, Zhou W, Greco A, Joshi A, Rayner B, Townsend S, Buson A, Jarolimek W. The lysyl oxidase like 2/3 enzymatic inhibitor, PXS-5153A, reduces crosslinks and ameliorates fibrosis. J Cell Mol Med. 2018 Dec 9. doi: 10.1111/jcmm.14074. [Epub ahead of print] PubMed PMID: 30536539.

2: Okada K, Moon HJ, Finney J, Meier A, Mure M. Extracellular processing of lysyl oxidase-like 2 and its effect on amine oxidase activity. Biochemistry. 2018 Nov 30. doi: 10.1021/acs.biochem.8b01008. [Epub ahead of print] PubMed PMID: 30499665.

3: Shao S, Zhang X, Duan L, Fang H, Rao S, Liu W, Guo B, Zhang X. Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway. Med Sci Monit. 2018 Nov 27;24:8592-8601. doi: 10.12659/MSM.910761. PubMed PMID: 30481795.

4: Baek JH, Yun HS, Kwon GT, Kim JY, Lee CW, Song JY, Um HD, Kang CM, Park JK, Kim JS, Kim EH, Hwang SG. PLOD3 promotes lung metastasis via regulation of STAT3. Cell Death Dis. 2018 Nov 15;9(12):1138. doi: 10.1038/s41419-018-1186-5. PubMed PMID: 30442941; PubMed Central PMCID: PMC6237925.

5: Khalifa I, Peng J, Jia Y, Li J, Zhu W, Yu-Juan X, Li C. Anti-glycation and anti-hardening effects of microencapsulated mulberry polyphenols in high-protein-sugar ball models through binding with some glycation sites of whey proteins. Int J Biol Macromol. 2018 Nov 5;123:10-19. doi: 10.1016/j.ijbiomac.2018.11.016. [Epub ahead of print] PubMed PMID: 30408455.

6: de Jong OG, van der Waals LM, Kools FRW, Verhaar MC, van Balkom BWM. Lysyl oxidase-like 2 is a regulator of angiogenesis through modulation of endothelial-to-mesenchymal transition. J Cell Physiol. 2018 Nov 1. doi: 10.1002/jcp.27695. [Epub ahead of print] PubMed PMID: 30387148.

7: Chan TK, Alkaabi MK, ElBarky AM, El-Hattab AW. LOXL3 novel mutation causing a rare form of autosomal recessive Stickler syndrome. Clin Genet. 2018 Oct 26. doi: 10.1111/cge.13465. [Epub ahead of print] PubMed PMID: 30362103.

8: Sarabia-Sainz HM, Ezquerra-Brauer JM, Santacruz-Ortega HC, Rouzaud-Sández O, Valenzuela-Soto EM, Acosta-Elias M, Torres-Arreola W. Muscle lysyl oxidase activity and structural/thermal properties of highly cross-linked collagen in jumbo squid (Dosidicus gigas) mantle, fins and arms. Food Sci Biotechnol. 2017 Dec 29;27(1):57-64. doi: 10.1007/s10068-017-0242-8. eCollection 2018 Feb. PubMed PMID: 30263724; PubMed Central PMCID: PMC6049768.

9: Kang J, Chun YS, Huh J, Park JW. FIH permits NAA10 to catalyze the oxygen-dependent lysyl-acetylation of HIF-1α. Redox Biol. 2018 Oct;19:364-374. doi: 10.1016/j.redox.2018.09.002. Epub 2018 Sep 7. PubMed PMID: 30237125; PubMed Central PMCID: PMC6142190.

10: Mochida K, Ito K, Ito M, Hano T, Ohkubo N. Toxicity of the biocide polycarbamate, used for aquaculture nets, to some marine fish species. Comp Biochem Physiol C Toxicol Pharmacol. 2018 Dec;214:61-67. doi: 10.1016/j.cbpc.2018.09.001. Epub 2018 Sep 7. PubMed PMID: 30201584.

11: Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ. Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26. FEBS Lett. 2018 Oct;592(19):3264-3273. doi: 10.1002/1873-3468.13231. Epub 2018 Sep 14. PubMed PMID: 30156264; PubMed Central PMCID: PMC6220849.

12: Hudson DM, Archer M, King KB, Eyre DR. Glycation of type I collagen selectively targets the same helical domain lysine sites as lysyl oxidase-mediated cross-linking. J Biol Chem. 2018 Oct 5;293(40):15620-15627. doi: 10.1074/jbc.RA118.004829. Epub 2018 Aug 24. PubMed PMID: 30143533; PubMed Central PMCID: PMC6177574.

13: Joung JW, Oh HK, Lee SJ, Kim YA, Jung HJ. Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma. J Pathol Transl Med. 2018 Sep;52(5):323-330. doi: 10.4132/jptm.2018.07.21. Epub 2018 Aug 19. PubMed PMID: 30121971; PubMed Central PMCID: PMC6166018.

14: Kamel M, Wagih M, Kilic GS, Diaz-Arrastia CR, Baraka MA, Salama SA. Erratum to "Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases". Biomed Res Int. 2018 Jul 18;2018:2420836. doi: 10.1155/2018/2420836. eCollection 2018. PubMed PMID: 30112368; PubMed Central PMCID: PMC6077682.

15: Schräder CU, Heinz A, Majovsky P, Karaman Mayack B, Brinckmann J, Sippl W, Schmelzer CEH. Elastin is heterogeneously cross-linked. J Biol Chem. 2018 Sep 28;293(39):15107-15119. doi: 10.1074/jbc.RA118.004322. Epub 2018 Aug 14. PubMed PMID: 30108173; PubMed Central PMCID: PMC6166741.

16: Scietti L, Chiapparino A, De Giorgi F, Fumagalli M, Khoriauli L, Nergadze S, Basu S, Olieric V, Cucca L, Banushi B, Profumo A, Giulotto E, Gissen P, Forneris F. Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3. Nat Commun. 2018 Aug 8;9(1):3163. doi: 10.1038/s41467-018-05631-5. Erratum in: Nat Commun. 2018 Sep 20;9(1):3912. PubMed PMID: 30089812; PubMed Central PMCID: PMC6082870.

17: Vallet SD, Miele AE, Uciechowska-Kaczmarzyk U, Liwo A, Duclos B, Samsonov SA, Ricard-Blum S. Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners. Sci Rep. 2018 Aug 6;8(1):11768. doi: 10.1038/s41598-018-30190-6. PubMed PMID: 30082873; PubMed Central PMCID: PMC6078952.

18: Qi Y, Xu R. Roles of PLODs in Collagen Synthesis and Cancer Progression. Front Cell Dev Biol. 2018 Jun 28;6:66. doi: 10.3389/fcell.2018.00066. eCollection 2018. Review. PubMed PMID: 30003082; PubMed Central PMCID: PMC6031748.

19: Romagnuolo R, DeMarco K, Scipione CA, Boffa MB, Koschinsky ML. Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells. Thromb Res. 2018 Sep;169:1-7. doi: 10.1016/j.thromres.2018.07.002. Epub 2018 Jul 4. PubMed PMID: 29990619.

20: Kaminski AM, Tumbale PP, Schellenberg MJ, Williams RS, Williams JG, Kunkel TA, Pedersen LC, Bebenek K. Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis. Nat Commun. 2018 Jul 6;9(1):2642. doi: 10.1038/s41467-018-05024-8. PubMed PMID: 29980672; PubMed Central PMCID: PMC6035275.