WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564355
Description: 10-FTHF is a donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
MedKoo Cat#: 564355
Chemical Formula: C20H23N7O7
Exact Mass: 473.1659
Molecular Weight: 473.45
Elemental Analysis: C, 50.74; H, 4.90; N, 20.71; O, 23.65
This product is not in stock, which may be available by custom synthesis.
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Synonym: 10-Formyltetrahydrofolic acid; 10-Formyl-THF; 10FTHF; 10 FTHF; 10-FTHF
IUPAC/Chemical Name: N-(10-Formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
InChi Key: AUFGTPPARQZWDO-YUZLPWPTSA-N
InChi Code: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11?,13-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(C=O)CC2NC3=C(NC2)N=C(N)NC3=O)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 473.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lin CC, Chuankhayan P, Chang WN, Kao TT, Guan HH, Fun HK, Nakagawa A, Fu TF, Chen CJ. Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition. Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):1006-21. doi: 10.1107/S1399004715002928. Epub 2015 Mar 27. PubMed PMID: 25849409; PubMed Central PMCID: PMC4388273.
2: Sah S, Aluri S, Rex K, Varshney U. One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia. J Bacteriol. 2015 Feb 15;197(4):717-26. doi: 10.1128/JB.02365-14. Epub 2014 Dec 1. PubMed PMID: 25448816; PubMed Central PMCID: PMC4334196.
3: Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R. A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development. Hum Mol Genet. 2013 Sep 15;22(18):3705-19. doi: 10.1093/hmg/ddt223. Epub 2013 May 23. PubMed PMID: 23704330.