Leucomycin a5
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MedKoo CAT#: 598658

CAS#: 18361-45-0

Description: Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimurium, or E. coli with MICs ranging from 5 to >10 µg/ml. Leucomycin A5 is also active against penicillin-susceptible and -resistant S. pyogenes (MICs = 0.8 and 3.2 µg/ml, respectively) and S. faecalis (MIC = 0.8 µg/ml).

Chemical Structure

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Leucomycin a5
CAS# 18361-45-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 598658
Name: Leucomycin a5
CAS#: 18361-45-0
Chemical Formula: C39H65NO14
Exact Mass: 771.44
Molecular Weight: 771.942
Elemental Analysis: C, 60.68; H, 8.49; N, 1.81; O, 29.02

Price and Availability

Size Price Availability Quantity
1mg USD 450 2 Weeks
5mg USD 1450 2 Weeks
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Synonym: Leucomycin a5; Leukomycin A5; Turimycin H4;

IUPAC/Chemical Name: (2S,3S,4R,6S)-6-(((2R,3S,4R,5R,6S)-6-(((4R,5S,6S,7R,9R,10R,11Z,13E,16R)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl)oxy)-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl butyrate

InChi Key: JZVYPSLDMXOITF-SVEPQRSMSA-N

InChi Code: InChI=1S/C39H65NO14/c1-10-14-29(44)52-37-25(5)50-31(21-39(37,6)47)53-34-24(4)51-38(33(46)32(34)40(7)8)54-35-26(17-18-41)19-22(2)27(42)16-13-11-12-15-23(3)49-30(45)20-28(43)36(35)48-9/h11-13,16,18,22-28,31-38,42-43,46-47H,10,14-15,17,19-21H2,1-9H3/b12-11+,16-13-/t22-,23-,24-,25+,26+,27+,28-,31+,32-,33-,34-,35+,36+,37+,38+,39-/m1/s1

SMILES Code: O[C@H]1[C@H](OC)[C@@H](O[C@@H]2O[C@H](C)[C@H]([C@H](N(C)C)[C@H]2O)O[C@@H]3O[C@@H](C)[C@H](OC(CCC)=O)[C@@](O)(C)C3)[C@H](C[C@@H](C)[C@@H](O)/C=C\C=C\C[C@@H](C)OC(C1)=O)CC=O

Appearance: Solid powder

Purity: >85% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: A macrolide antibiotic.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 771.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Yamashita K, Kinoshita K. X-ray crystallographies of leucomycin A5 and rokitamycin monomethylacetal. J Antibiot (Tokyo). 1997 Nov;50(11):975-8. PubMed PMID: 9592575.

2: Hu M, Hu CQ. [Identification of the components and products of hydrolysis in acetylleucomycin by LC-MS]. Yao Xue Xue Bao. 2006 May;41(5):476-80. Chinese. PubMed PMID: 16848328.