ML327
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407921

CAS#: 1883510-31-3

Description: ML327 is a blocker of MYC. ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition. ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand. ML327 blocks MYC expression and tumor formation in neuroblastoma.


Price and Availability

Size
Price

100mg
USD 950
1g
USD 3250
Size
Price

200mg
USD 1450
2g
USD 5250
Size
Price

500mg
USD 2450
5g
USD 7650

ML-327, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407921
Name: ML327
CAS#: 1883510-31-3
Chemical Formula: C19H18N4O4
Exact Mass: 366.1328
Molecular Weight: 366.38
Elemental Analysis: C, 62.29; H, 4.95; N, 15.29; O, 17.47


Synonym: ML-327; ML 327; ML327.

IUPAC/Chemical Name: N-(3-(2-oxo-1,2-dihydropyridine-3-carboxamido)propyl)-5-phenylisoxazole-3-carboxamide

InChi Key: NNNDNXLMQAPQQQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N4O4/c24-17-14(8-4-9-20-17)18(25)21-10-5-11-22-19(26)15-12-16(27-23-15)13-6-2-1-3-7-13/h1-4,6-9,12H,5,10-11H2,(H,20,24)(H,21,25)(H,22,26)

SMILES Code: C1C=CNC(=O)C=1C(=O)NCCCNC(=O)C1=NOC(C2=CC=CC=C2)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Padmanabhan C, Rellinger EJ, Zhu J, An H, Woodbury LG, Chung DH, Waterson AG, Lindsley CW, Means AL, Beauchamp RD. cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition. Oncotarget. 2017 Jul 25;8(60):101072-101086. doi: 10.18632/oncotarget.19557. eCollection 2017 Nov 24. PubMed PMID: 29254146; PubMed Central PMCID: PMC5731856.

2: Rellinger EJ, Padmanabhan C, Qiao J, Craig BT, An H, Zhu J, Correa H, Waterson AG, Lindsley CW, Beauchamp RD, Chung DH. Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma. Oncotarget. 2017 Jul 20;8(53):91040-91051. doi: 10.18632/oncotarget.19406. eCollection 2017 Oct 31. PubMed PMID: 29207623; PubMed Central PMCID: PMC5710904.

3: Rellinger EJ, Padmanabhan C, Qiao J, Appert A, Waterson AG, Lindsley CW, Beauchamp RD, Chung DH. ML327 induces apoptosis and sensitizes Ewing sarcoma cells to TNF-related apoptosis-inducing ligand. Biochem Biophys Res Commun. 2017 Sep 16;491(2):463-468. doi: 10.1016/j.bbrc.2017.07.050. Epub 2017 Jul 14. PubMed PMID: 28716733; PubMed Central PMCID: PMC5564678.

4: Stoops SL, Waterson AG, An H, Deane N, Daniels JS, Morrison R, Engers JL, Beauchamp D, Lindsley CW. Discovery and characterization of a small molecule that restores E-cadherin expression in cancer cell lines via a new mechanism. 2012 Dec 13 [updated 2013 Mar 22]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK344134/ PubMed PMID: 26913352.

5: Brogan JT, Stoops SL, Brady S, An H, Weaver C, Daniels JS, Beauchamp RD, Lindsley CW, Waterson AG. Optimization of a small molecule probe that restores e-cadherin expression. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4260-4. doi: 10.1016/j.bmcl.2015.07.104. Epub 2015 Aug 6. PubMed PMID: 26299347; PubMed Central PMCID: PMC4567403.

6: An H, Stoops SL, Deane NG, Zhu J, Zi J, Weaver C, Waterson AG, Zijlstra A, Lindsley CW, Beauchamp RD. Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition. Oncotarget. 2015 Sep 8;6(26):22934-48. PubMed PMID: 26082441; PubMed Central PMCID: PMC4673210.