TG53 | CAS#946369-04-6 | interaction inhibitor

TG53
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563133

CAS#: 946369-04-6

Description: TG53 is an inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction.

Chemical Structure

TG53

CAS# 946369-04-6

Instruction

Theoretical Analysis

MedKoo Cat#: 563133
Name: TG53
CAS#: 946369-04-6
Chemical Formula: C21H22ClN5O2
Exact Mass: 411.15
Molecular Weight: 411.890
Elemental Analysis: C, 61.24; H, 5.38; Cl, 8.61; N, 17.00; O, 7.77

Price and Availability

Size	Price	Availability
25mg	USD 250	2 Weeks
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 4250	2 Weeks
2g	USD 6950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 946369-04-6

Synonym: TG53; TG-53; TG 53

IUPAC/Chemical Name: 5-Chloro-N-[4-[[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino]phenyl]-2-methoxy-benzamide

InChi Key: JHHHSGYKBKIUBG-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22ClN5O2/c1-13-11-19(27(2)3)26-21(23-13)25-16-8-6-15(7-9-16)24-20(28)17-12-14(22)5-10-18(17)29-4/h5-12H,1-4H3,(H,24,28)(H,23,25,26)

SMILES Code: O=C(NC1=CC=C(NC2=NC(C)=CC(N(C)C)=N2)C=C1)C3=CC(Cl)=CC=C3OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Certificate of Analysis:

View CoA: current batch, Lot#A23O08B08

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 411.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Yakubov B, Chen L, Belkin AM, Zhang S, Chelladurai B, Zhang ZY, Matei D. Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction. PLoS One. 2014 Feb 20;9(2):e89285. doi: 10.1371/journal.pone.0089285. eCollection 2014. PubMed PMID: 24586660; PubMed Central PMCID: PMC3930694.

2: Herrera VL, Ponce LR, Ruiz-Opazo N. Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats. J Hypertens. 2007 Aug;25(8):1608-12. PubMed PMID: 17620956.

3: Herrera VL, Shen L, Lopez LV, Didishvili T, Zhang YX, Ruiz-Opazo N. Chlamydia pneumoniae accelerates coronary artery disease progression in transgenic hyperlipidemia-genetic hypertension rat model. Mol Med. 2003 May-Aug;9(5-8):135-42. PubMed PMID: 14571321; PubMed Central PMCID: PMC1430827.

4: Herrera VM, Didishvili T, Lopez LV, Zander K, Traverse S, Gantz D, Herscovitz H, Ruiz-Opazo N. Hypertension exacerbates coronary artery disease in transgenic hyperlipidemic Dahl salt-sensitive hypertensive rats. Mol Med. 2001 Dec;7(12):831-44. PubMed PMID: 11844871; PubMed Central PMCID: PMC1950013.

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TG53 featured