WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597183
CAS#: 54931-98-5
Description: 10-Thiofolic acid is a potential antibacterial, antineoplastic agent.
MedKoo Cat#: 597183
Name: 10-Thiofolic acid
CAS#: 54931-98-5
Chemical Formula: C19H18N6O6S
Exact Mass: 458.1009
Molecular Weight: 458.44
Elemental Analysis: C, 49.78; H, 3.96; N, 18.33; O, 20.94; S, 6.99
This product is not in stock, which may be available by custom synthesis.
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Synonym: 10-Thiofolic acid; NSC 238147; NSC-238147; NSC238147;
IUPAC/Chemical Name: (4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)thio)benzoyl)-L-glutamic acid
InChi Key: VUCAAEQMBTVEOL-LBPRGKRZSA-N
InChi Code: InChI=1S/C19H18N6O6S/c20-19-24-15-14(17(29)25-19)22-10(7-21-15)8-32-11-3-1-9(2-4-11)16(28)23-12(18(30)31)5-6-13(26)27/h1-4,7,12H,5-6,8H2,(H,23,28)(H,26,27)(H,30,31)(H3,20,21,24,25,29)/t12-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(SCC2=CN=C3NC(N)=NC(C3=N2)=O)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 458.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nair MG, Campbell PT, Baugh CM. Synthesis of 10-thiofolic acid. A potential antibacterial and antitumor agent. J Org Chem. 1975 Jun 13;40(12):1745-8. PubMed PMID: 1133602.
