10-Formylfolic acid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597165

CAS#: 134-05-4

Description: 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase.


Price and Availability

Size
Price

25mg
USD 1350
Size
Price

Size
Price

10-Formylfolic acid purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597165
Name: 10-Formylfolic acid
CAS#: 134-05-4
Chemical Formula: C20H19N7O7
Exact Mass: 469.1346
Molecular Weight: 469.41
Elemental Analysis: C, 51.17; H, 4.08; N, 20.89; O, 23.86


Synonym: 10-Formylfolic acid;

IUPAC/Chemical Name: (4-(N-((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)formamido)benzoyl)-L-glutamic acid

InChi Key: UGWUWNVTCLDEOG-ZDUSSCGKSA-N

InChi Code: InChI=1S/C20H19N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,7,9,13H,5-6,8H2,(H,24,31)(H,29,30)(H,33,34)(H3,21,22,25,26,32)/t13-/m0/s1

SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=CN=C3NC(N)=NC(C3=N2)=O)C=O)C=C1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Ashokkumar K, Sivakumar P, Saradhadevi M. Identification and determination of naturally occurring folates in grains of rice (Oryza sativa L.) by UPLC-MS/MS analysis. Nat Prod Res. 2018 Jul;32(14):1733-1737. doi: 10.1080/14786419.2017.1392957. Epub 2017 Oct 23. PubMed PMID: 29058482.

2: Kopp M, Morisset R, Rychlik M. Characterization and Interrelations of One-Carbon Metabolites in Tissues, Erythrocytes, and Plasma in Mice with Dietary Induced Folate Deficiency. Nutrients. 2017 May 5;9(5). pii: E462. doi: 10.3390/nu9050462. PubMed PMID: 28475162; PubMed Central PMCID: PMC5452192.

3: Kopp M, Dürr K, Steigleder M, Clavel T, Rychlik M. Development of stable isotope dilution assays for the quantitation of intra- and extracellular folate patterns of Bifidobacterium adolescentis. J Chromatogr A. 2016 Oct 21;1469:48-59. doi: 10.1016/j.chroma.2016.09.048. Epub 2016 Sep 22. PubMed PMID: 27692648.

4: Kopp M, Morisset R, Koehler P, Rychlik M. Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. PLoS One. 2016 Jun 8;11(6):e0156610. doi: 10.1371/journal.pone.0156610. eCollection 2016. PubMed PMID: 27276031; PubMed Central PMCID: PMC4898732.

5: Büttner BE, Öhrvik VE, Witthöft CM, Rychlik M. Quantification of isotope-labelled and unlabelled folates in plasma, ileostomy and food samples. Anal Bioanal Chem. 2011 Jan;399(1):429-39. doi: 10.1007/s00216-010-4313-4. Epub 2010 Oct 30. PubMed PMID: 21052651.

6: Kariluoto S, Edelmann M, Herranen M, Lampi AM, Shmelev A, Salovaara H, Korhola M, Piironen V. Production of folate by bacteria isolated from oat bran. Int J Food Microbiol. 2010 Sep 30;143(1-2):41-7. doi: 10.1016/j.ijfoodmicro.2010.07.026. Epub 2010 Aug 11. PubMed PMID: 20708290.

7: Mönch S, Netzel M, Netzel G, Rychlik M. Quantitation of folates and their catabolites in blood plasma, erythrocytes, and urine by stable isotope dilution assays. Anal Biochem. 2010 Mar 15;398(2):150-60. doi: 10.1016/j.ab.2009.11.007. Epub 2009 Nov 10. PubMed PMID: 19903444.

8: De Brouwer V, Zhang GF, Storozhenko S, Straeten DV, Lambert WE. pH stability of individual folates during critical sample preparation steps in prevision of the analysis of plant folates. Phytochem Anal. 2007 Nov-Dec;18(6):496-508. PubMed PMID: 17624887.

9: Patring JD, Jastrebova JA. Application of liquid chromatography-electrospray ionisation mass spectrometry for determination of dietary folates: effects of buffer nature and mobile phase composition on sensitivity and selectivity. J Chromatogr A. 2007 Mar 2;1143(1-2):72-82. Epub 2006 Dec 23. PubMed PMID: 17210159.

10: Patring JD, Lanina SA, Jastrebova JA. Applicability of alkyl-bonded ultra-pure silica stationary phases for gradient reversed-phase HPLC of folates with conventional and volatile buffers under highly aqueous conditions. J Sep Sci. 2006 Apr;29(6):889-904. PubMed PMID: 16830501.

11: Zhang GF, Storozhenko S, Van Der Straeten D, Lambert WE. Investigation of the extraction behavior of the main monoglutamate folates from spinach by liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr A. 2005 Jun 17;1078(1-2):59-66. PubMed PMID: 16007982.

12: Patring JD, Jastrebova JA, Hjortmo SB, Andlid TA, Jägerstad IM. Development of a simplified method for the determination of folates in baker's yeast by HPLC with ultraviolet and fluorescence detection. J Agric Food Chem. 2005 Apr 6;53(7):2406-11. PubMed PMID: 15796570.

13: Rychlik M, Netzel M, Pfannebecker I, Frank T, Bitsch I. Application of stable isotope dilution assays based on liquid chromatography-tandem mass spectrometry for the assessment of folate bioavailability. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 25;792(2):167-76. PubMed PMID: 12860024.

14: Freisleben A, Schieberle P, Rychlik M. Comparison of folate quantification in foods by high-performance liquid chromatography-fluorescence detection to that by stable isotope dilution assays using high-performance liquid chromatography-tandem mass spectrometry. Anal Biochem. 2003 Apr 15;315(2):247-55. PubMed PMID: 12689834.

15: Freisleben A, Schieberle P, Rychlik M. Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays. J Agric Food Chem. 2002 Aug 14;50(17):4760-8. PubMed PMID: 12166957.

16: Ruggeri S, Vahteristo LT, Aguzzi A, Finglas P, Carnovale E. Determination of folate vitamers in food and in Italian reference diet by high-performance liquid chromatography. J Chromatogr A. 1999 Sep 3;855(1):237-45. PubMed PMID: 10514988.

17: Konings EJ. A validated liquid chromatographic method for determining folates in vegetables, milk powder, liver, and flour. J AOAC Int. 1999 Jan-Feb;82(1):119-27. PubMed PMID: 10028680.

18: Vahteristo LT, Ollilainen V, Varo P. Liquid chromatographic determination of folate monoglutamates in fish, meat, egg, and dairy products consumed in Finland. J AOAC Int. 1997 Mar-Apr;80(2):373-8. PubMed PMID: 9086593.

19: Baggott JE, Johanning GL, Branham KE, Prince CW, Morgan SL, Eto I, Vaughn WH. Cofactor role for 10-formyldihydrofolic acid. Biochem J. 1995 Jun 15;308 ( Pt 3):1031-6. PubMed PMID: 8948466; PubMed Central PMCID: PMC1136826.

20: White D, Varlashkin P, Rusch DN. A thin-layer chromatographic method to determine process impurities in leucovorin calcium. J Pharm Sci. 1992 Dec;81(12):1204-9. PubMed PMID: 1491341.