0990CL
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MedKoo CAT#: 562975

CAS#: 511514-03-7

Description: 0990CL is an inhibitor of heterotrimeric Gαi subunits. 0990CL showed direct interaction with Gαi. Several compounds showed Gαi specific inhibition and were able to block α2AR mediated regulation of cAMP.


Chemical Structure

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0990CL
CAS# 511514-03-7

Theoretical Analysis

MedKoo Cat#: 562975
Name: 0990CL
CAS#: 511514-03-7
Chemical Formula: C21H21N5
Exact Mass: 343.18
Molecular Weight: 343.430
Elemental Analysis: C, 73.44; H, 6.16; N, 20.39

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 weeks
10mg USD 750 2 weeks
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Synonym: 0990CL; 0990-CL; 0990 CL;

IUPAC/Chemical Name: (4-Phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine

InChi Key: DXICUHJLOMNKOU-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26)

SMILES Code: CC1(C)C=C(C)N=C(NC2=NC(C3=CC=CC=C3)=C4C=CC=CC4=N2)N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: 0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.0 145.59

Preparing Stock Solutions

The following data is based on the product molecular weight 343.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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Appleton KM, Bigham KJ, Lindsey CC, Hazard S, Lirjoni J, Parnham S, Hennig M, Peterson YK. Development of inhibitors of heterotrimeric Gαi subunits. Bioorg Med Chem. 2014 Jul 1;22(13):3423-34. doi: 10.1016/j.bmc.2014.04.035. Epub 2014 Apr 26. PMID: 24818958; PMCID: PMC4103618.