CHM-081
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596378

CAS#: 1373876-34-6

Description: JWH 081 is a cannabimimetic aminoalkylindole that shows a high-affinity for the central cannabinoid (CB1) receptor with a Ki value of 1.2 nM and ten-fold reduced affinity for the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM). JWH 081-N-(cyclohexylmethyl) analog is a synthetic CB where a cyclohexylmethyl group replaces the alkyl group of the parent compound. The physiological and toxicological properties of this compound are unknown.

Chemical Structure

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CHM-081
CAS# 1373876-34-6
Instruction

Theoretical Analysis

MedKoo Cat#: 596378
Name: CHM-081
CAS#: 1373876-34-6
Chemical Formula: C27H27NO2
Exact Mass: 397.20
Molecular Weight: 397.510
Elemental Analysis: C, 81.58; H, 6.85; N, 3.52; O, 8.05

Price and Availability

Size Price Availability Quantity
1mg USD 240
5mg USD 580
10mg USD 970
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Synonym: CHM-081; CHM 081; CHM081;

IUPAC/Chemical Name: (1-(cyclohexylmethyl)-1H-indol-3-yl)(4-methoxynaphthalen-1-yl)methanone

InChi Key: LMENRXZOUBANKQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H27NO2/c1-30-26-16-15-23(20-11-5-6-13-22(20)26)27(29)24-18-28(17-19-9-3-2-4-10-19)25-14-8-7-12-21(24)25/h5-8,11-16,18-19H,2-4,9-10,17H2,1H3

SMILES Code: O=C(C1=CN(CC2CCCCC2)C3=C1C=CC=C3)C4=C5C=CC=CC5=C(OC)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 397.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Blakey K, Boyd S, Atkinson S, Wolf J, Slottje PM, Goodchild K, McGowan J. Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense. Forensic Sci Int. 2016 Mar;260:40-53. doi: 10.1016/j.forsciint.2015.12.001. Epub 2015 Dec 14. PubMed PMID: 26795397.