WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562547
Description: 1,4-DPCA is a potent and selective inhibitor of prolyl 4-hydroxylase.
MedKoo Cat#: 562547
Chemical Formula: C13H8N2O3
Exact Mass: 240.0535
Molecular Weight: 240.218
Elemental Analysis: C, 65.00; H, 3.36; N, 11.66; O, 19.98
Synonym: 1,4-DPCA; 1,4 DPCA; 1,4DPCA;
IUPAC/Chemical Name: 4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid
InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18)
SMILES Code: O=C(C(C(O)=O)=CN1)C2=C1C3=C(C=C2)C=CC=N3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 240.218 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhang Y, Strehin I, Bedelbaeva K, Gourevitch D, Clark L, Leferovich J, Messersmith PB, Heber-Katz E. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. doi: 10.1126/scitranslmed.3010228. PubMed PMID: 26041709; PubMed Central PMCID: PMC4687906.
2: Xiong G, Deng L, Zhu J, Rychahou PG, Xu R. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. doi: 10.1186/1471-2407-14-1. PubMed PMID: 24383403; PubMed Central PMCID: PMC3880410.
3: Love RJ, Jones KS. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606. doi: 10.1002/jbm.a.34648. Epub 2013 Jun 14. PubMed PMID: 23766241.