Tiletamine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526457

CAS#: 14176-49-9 (free base)

Description: Tiletamine has been discontinued.

Chemical Structure

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Tiletamine
CAS# 14176-49-9 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 526457
Name: Tiletamine
CAS#: 14176-49-9 (free base)
Chemical Formula: C12H17NOS
Exact Mass: 223.10
Molecular Weight: 223.334
Elemental Analysis: C, 64.54; H, 7.67; N, 6.27; O, 7.16; S, 14.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 14176-50-2 (HCl)   14176-49-9 (free base)    

Synonym: Tiletamine

IUPAC/Chemical Name: Cyclohexanone, 2-(ethylamino)-2-(2-thienyl)-

InChi Key: QAXBVGVYDCAVLV-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3

SMILES Code: O=C1C(C2=CC=CS2)(NCC)CCCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 223.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kolesnikova TO, Khatsko SL, Shevyrin VA, Morzherin YY, Kalueff AV. Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish. Neurotoxicol Teratol. 2016 Dec 2. pii: S0892-0362(16)30154-4. doi: 10.1016/j.ntt.2016.11.009. [Epub ahead of print] PubMed PMID: 27916716.

2: Khokhlova ON, Tukhovskaya EA, Kravchenko IN, Sadovnikova ES, Pakhomova IA, Kalabina EA, Lobanov AV, Shaykhutdinova ER, Ismailova AM, Murashev AN. Using Tiletamine-Zolazepam-Xylazine Anesthesia Compared to CO(2)-inhalation for Terminal Clinical Chemistry, Hematology, and Coagulation Analysis in Mice. J Pharmacol Toxicol Methods. 2016 Oct 20;84:11-19. doi: 10.1016/j.vascn.2016.10.005. [Epub ahead of print] PubMed PMID: 27773843.

3: Jeong DH, Yang JJ, Seok SH, Song DJ, Yeon SC. Cardiorespiratory effects of isoflurane in Asiatic black bears (Ursus thibetanus) anesthetized with intramuscular medetomidine and zolazepam/tiletamine. J Vet Med Sci. 2016 Sep 30. [Epub ahead of print] PubMed PMID: 27725350.

4: Conforti VA, de Azevedo FC, de Oliveira Henriques Paulo OL, de Moraes W, Deddens JA. Chemical Restraint of Free-ranging South American Coatis ( Nasua nasua ) with a Combination of Tiletamine and Zolazepam. J Wildl Dis. 2016 Oct 5. [Epub ahead of print] PubMed PMID: 27705101.

5: Seddighi R, Odoi A, Doherty TJ. Effect of dexmedetomidine hydrochloride on tiletamine hydrochloride-zolazepam hydrochloride anesthesia in alpacas. Am J Vet Res. 2016 Oct;77(10):1057-63. doi: 10.2460/ajvr.77.10.1057. PubMed PMID: 27668576.

6: de la Peña JB, Cheong JH. The abuse liability of the NMDA receptor antagonist-benzodiazepine (tiletamine-zolazepam) combination: evidence from clinical case reports and preclinical studies. Drug Test Anal. 2016 Aug;8(8):760-7. doi: 10.1002/dta.1987. Review. PubMed PMID: 27341080.

7: Yanmaz LE, Doğan E, Ersöz U, Okumuş Z, Doğan V. Anaesthesia in a Eurasian lynx with an intranasal zolazepam-tiletamine combination. Vet Anaesth Analg. 2016 Jun 16. doi: 10.1111/vaa.12403. [Epub ahead of print] PubMed PMID: 27306966.

8: Yanmaz LE, Dogan E, Okur S, Okumus Z, Ersoz U. Comparison of the effects of intranasal and intramuscular administrations of zolazepam-tiletamine combination on intraocular pressure in cats. Vet Ophthalmol. 2016 Jul;19 Suppl 1:115-8. doi: 10.1111/vop.12400. PubMed PMID: 27302830.

9: Arun AS, Krishna S, Antony L, Pillai HC, Venkataramanappa M, Suresh S. Effective Reversible Immobilization of Captive Himalayan Black Bears (Selenarctos thibetanus laniger) with Medetomidine-Tiletamine-Zolazepam and Atipamezole. J Wildl Dis. 2016 Apr 28;52(2):400-2. doi: 10.7589/2014-08-206. PubMed PMID: 27124333.

10: Spada E, Proverbio D, Baggiani L, Bagnagatti De Giorgi G, Ferro E, Perego R. Change in haematological and selected biochemical parameters measured in feline blood donors and feline whole blood donated units. J Feline Med Surg. 2016 Feb 3. pii: 1098612X16628919. [Epub ahead of print] PubMed PMID: 26842942.

11: Cecchetto C, Mahmud M, Vassanelli S. Anesthesia effect on single local field potentials variability in rat barrel cortex: Preliminary results. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:4721-4. doi: 10.1109/EMBC.2015.7319448. PubMed PMID: 26737348.

12: Raposo AC, Ofri R, Schaffer DP, Gomes Júnior DC, Libório FA, Martins Filho EF, Oriá AP. Evaluation of ophthalmic and hemodynamic parameters in capuchin monkeys (Sapajus sp.) submitted to dissociative anesthetic protocols. J Med Primatol. 2015 Dec;44(6):381-9. doi: 10.1111/jmp.12200. PubMed PMID: 26457384.

13: Kim J, Yum H, Jang M, Shin I, Yang W, Baeck S, Suh JH, Lee S, Han SB. A comprehensive and sensitive method for hair analysis in drug-facilitated crimes and incorporation of zolazepam and tiletamine into hair after a single exposure. Anal Bioanal Chem. 2016 Jan;408(1):251-63. doi: 10.1007/s00216-015-9099-y. PubMed PMID: 26454443.

14: Choi SY, Jeong WC, Lee YW, Choi HJ. Contrast enhanced ultrasonography of kidney in conscious and anesthetized beagle dogs. J Vet Med Sci. 2016 Feb;78(2):239-44. doi: 10.1292/jvms.15-0199. PubMed PMID: 26412201; PubMed Central PMCID: PMC4785112.

15: Springer A, Razafimanantsoa L, Fichtel C, Kappeler PM. COMPARISON OF THREE SHORT-TERM IMMOBILIZATION REGIMES IN WILD VERREAUX'S SIFAKAS (PROPITHECUS VERREAUXI): KETAMINE-XYLAZINE, KETAMINE-XYLAZINE-ATROPINE, AND TILETAMINE-ZOLAZEPAM. J Zoo Wildl Med. 2015 Sep;46(3):482-90. doi: 10.1638/2014-0154.1. PubMed PMID: 26352951.

16: Jin Y, Qiao Y, Liu X, Pu T, Xu H, Lin D. Immobilization of wild giant panda (Ailuropoda melanoleuca) with dexmedetomidine-tiletamine-zolazepam. Vet Anaesth Analg. 2016 May;43(3):333-7. doi: 10.1111/vaa.12301. PubMed PMID: 26332691.

17: Chaves RH, Souza NF, Imbeloni AA, Neves AC, Teixeira RK, Santos Cde C. Evaluation of blood pressure in feline night monkeys (Aotus azarae infulatus) under different restraint protocols. J Med Primatol. 2015 Dec;44(6):349-54. doi: 10.1111/jmp.12183. PubMed PMID: 26222788.

18: De Monte V, Staffieri F, Di Meo A, Vannucci J, Bufalari A. Comparison of ketamine-dexmedetomidine-methadone and tiletamine-zolazepam-methadone combinations for short-term anaesthesia in domestic pigs. Vet J. 2015 Sep;205(3):364-8. doi: 10.1016/j.tvjl.2015.05.011. PubMed PMID: 26070949.

19: Ozeki LM, Caulkett N, Stenhouse G, Arnemo JM, Fahlman Å. EFFECT OF ACTIVE COOLING AND α-2 ADRENOCEPTOR ANTAGONISM ON CORE TEMPERATURE IN ANESTHETIZED BROWN BEARS (URSUS ARCTOS). J Zoo Wildl Med. 2015 Jun;46(2):279-85. doi: 10.1638/2014-0052R.1. PubMed PMID: 26056880.

20: Casas-Díaz E, Closa-Sebastià F, Marco I, Lavín S, Bach-Raich E, Cuenca R. Hematologic and biochemical reference intervals for Wild Boar (Sus scrofa) captured by cage trap. Vet Clin Pathol. 2015 Jun;44(2):215-22. doi: 10.1111/vcp.12250. PubMed PMID: 25899088.